GenAge entry for ARHGAP1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 249)

HGNC symbol
ARHGAP1 
Aliases
RhoGAP; p50rhoGAP; CDC42GAP; Cdc42GAP 
Common name
Rho GTPase activating protein 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

ARHGAP1 a GTPase activator of several proteins. In effect, it acts as a negative regulator of CDC42. Gene targeting of ARHGAP1 in mice results in a short lifespan of about 12 months and the development of multiple premature ageing-like phenotypes, suggesting that this gene may play a role in mammalian ageing [1840].

Cytogenetic information

Cytogenetic band
11p11.2
Location
46,677,075 bp to 46,700,665 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007264; small GTPase mediated signal transduction
GO:0007266; Rho protein signal transduction
GO:0051056; regulation of small GTPase mediated signal transduction
Cellular component: GO:0001726; ruffle
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0043231; intracellular membrane-bounded organelle
Function: GO:0005070; SH3/SH2 adaptor activity
GO:0005100; Rho GTPase activator activity
GO:0005515; protein binding
GO:0017124; SH3 domain binding
GO:0030675; Rac GTPase activator activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
CDC42
STRING interaction network
Protein-Protein network diagram for ARHGAP1

Retrieve sequences for ARHGAP1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
arhgap1
Mus musculus
Arhgap1
Rattus norvegicus
Arhgap1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Arhgap1

Selected references

External links

EPD
ORF Accession
NM_004308
CDS Accession
NP_004299
OMIM
602732
HPRD
04108
Ensembl
ARHGAP1
UniProt/Swiss-Prot
RHG01_HUMAN
GeneCards
ARHGAP1
Entrez Gene
392
UniGene
138860
GenAtlas
ARHGAP1
Internet
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