GenAge entry for XRCC5 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 112)

HGNC symbol
XRCC5 
Aliases
KU80; KARP-1; Ku86; KUB2 
Common name
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

XRCC5, or Ku80, is a helicase involved in DNA repair and chromatin remodelling [577]. It has been found associated with the telomeres [158] and with WRN [983]. XRCC5-null mice live about 38 weeks and appear to age prematurely [1490]. As such, XRCC5 may play a role in human ageing.

Cytogenetic information

Cytogenetic band
2q35
Location
216,109,297 bp to 216,206,293 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000723; telomere maintenance
GO:0006302; double-strand break repair
GO:0006303; double-strand break repair via nonhomologous end joining
GO:0006310; DNA recombination
GO:0006351; transcription, DNA-templated
GO:0007420; brain development
GO:0008283; cell proliferation
GO:0032481; positive regulation of type I interferon production
GO:0032508; DNA duplex unwinding
GO:0042493; response to drug
GO:0045892; negative regulation of transcription, DNA-templated
And 10 more GO terms
Cellular component: GO:0000783; nuclear telomere cap complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0016020; membrane
GO:0043564; Ku70:Ku80 complex
GO:0070419; nonhomologous end joining complex
Function: GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003691; double-stranded telomeric DNA binding
GO:0004003; ATP-dependent DNA helicase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0031625; ubiquitin protein ligase binding
GO:0042162; telomeric DNA binding
GO:0044212; transcription regulatory region DNA binding
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TERT, ATM, WRN, MYC, EGFR, PARP1, BRCA1, RPA1, TOP2A, TOP1, UBE2I, TERF1, PRKDC, AR, XRCC5, PCNA, TERF2, XRCC6, BAX, HSF1, BMI1, TFAP2A, APEX1, POLA1, NBN, H2AFX, HOXB7, HOXC4, CEBPA, ESR1, SIRT6, ATR, PPARG, SIRT7, TP53BP1
STRING interaction network
Protein-Protein network diagram for XRCC5

Retrieve sequences for XRCC5

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
cku-80
Danio rerio
xrcc5
Drosophila melanogaster
Ku80
Mus musculus
Xrcc5
Rattus norvegicus
Xrcc5
Schizosaccharomyces pombe
pku80

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Xrcc5
LongevityMap
  • This gene is present as XRCC5

Selected references

External links

EPD
ORF Accession
NM_021141
CDS Accession
NP_066964
OMIM
194364
HPRD
08935
Ensembl
XRCC5
UniProt/Swiss-Prot
KU86_HUMAN
GeneCards
XRCC5
Entrez Gene
7520
UniGene
388739
GenAtlas
XRCC5
Internet
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