GenAge entry for IL7R (Homo sapiens)

Gene name (HAGRID: 27)

HGNC symbol
IL7R 
Aliases
CD127 
Common name
interleukin 7 receptor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

IL7R is involved in inflammation and immune response. Though a role in human ageing has not been demonstrated, it is possible that IL7R is related to age-related changes and pathologies, namely, at the level of the immune system [296].

Cytogenetic information

Cytogenetic band
5p13
Location
35,856,875 bp to 35,879,603 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000018; regulation of DNA recombination
GO:0000902; cell morphogenesis
GO:0001915; negative regulation of T cell mediated cytotoxicity
GO:0002377; immunoglobulin production
GO:0006955; immune response
GO:0007165; signal transduction
GO:0007166; cell surface receptor signaling pathway
GO:0008361; regulation of cell size
GO:0010628; positive regulation of gene expression
GO:0016049; cell growth
GO:0030217; T cell differentiation
And 6 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005886; plasma membrane
GO:0009897; external side of plasma membrane
GO:0016021; integral to membrane
Function: GO:0003823; antigen binding
GO:0004917; interleukin-7 receptor activity
GO:0005515; protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GHR, STAT5B, STAT5A, PTK2B, IL7, PIK3R1
STRING interaction network
Protein-Protein network diagram for IL7R

Retrieve sequences for IL7R

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
il7r
Mus musculus
Il7r
Rattus norvegicus
Il7r

Selected references

External links

EPD
ORF Accession
NM_002185
CDS Accession
NP_002176
OMIM
146661
HPRD
00893
Ensembl
IL7R
UniProt/Swiss-Prot
IL7RA_HUMAN
GeneCards
IL7R
Entrez Gene
3575
UniGene
591742
GenAtlas
IL7R
Internet
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