GenAge entry for BDNF (Homo sapiens)

Gene name (HAGRID: 191)

HGNC symbol
BDNF 
Aliases
 
Common name
brain-derived neurotrophic factor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

BDNF is a growth factor that promotes neuronal survival and is involved in numerous neuronal responses.

Mice with an accelerated postnatal rise in BDNF showed a precocious development of some CNS features [833]. BDNF-deficient mice showed normal levels of serotonergic neurons at an early age but premature age-associated decrements [834]. Polymorphisms in the human BDNF gene have been associated with memory and hippocampal function [1727]. Age-related changes in BDNF have also been reported in rats [59]. In rats, BDNF has also been associated with changes in the heart [1646]. Although it is plausible that BDNF plays a role in some age-related pathologies, such as neurodegenerative diseases, its impact on human ageing has not been elucidated.

Cytogenetic information

Cytogenetic band
11p13
Location
27,654,895 bp to 27,659,649 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001657; ureteric bud development
GO:0001662; behavioral fear response
GO:0001666; response to hypoxia
GO:0002544; chronic inflammatory response
GO:0006120; mitochondrial electron transport, NADH to ubiquinone
GO:0007399; nervous system development
GO:0007406; negative regulation of neuroblast proliferation
GO:0007411; axon guidance
GO:0007412; axon target recognition
GO:0007611; learning or memory
GO:0007631; feeding behavior
And 21 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005737; cytoplasm
GO:0008021; synaptic vesicle
GO:0048471; perinuclear region of cytoplasm
Function: GO:0005169; neurotrophin TRKB receptor binding
GO:0008083; growth factor activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EGFR
STRING interaction network
Protein-Protein network diagram for BDNF

Retrieve sequences for BDNF

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
bdnf
Mus musculus
Bdnf
Rattus norvegicus
Bdnf

Selected references

External links

EPD
ORF Accession
NM_170735
CDS Accession
NP_733931
OMIM
113505
HPRD
00214
Ensembl
BDNF
UniProt/Swiss-Prot
BDNF_HUMAN
GeneCards
BDNF
Entrez Gene
627
UniGene
502182
GenAtlas
BDNF
Internet
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