GenAge entry for IGFBP3 (Homo sapiens)

Gene name (HAGRID: 73)

HGNC symbol
IGFBP3 
Aliases
IBP3; BP-53 
Common name
insulin-like growth factor binding protein 3 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

IGFBP3 is a member of the IGFBP family that regulates IGF1 and IGF2 by altering the interaction of IGFs with their cell surface receptors. Some evidence suggests that IGFBP3 influences age-related changes in lean body mass [457], but so far it has not been directly linked to human ageing.

Cytogenetic information

Cytogenetic band
7p13-p12
Location
45,912,245 bp to 45,921,272 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001558; regulation of cell growth
GO:0001649; osteoblast differentiation
GO:0001933; negative regulation of protein phosphorylation
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0008285; negative regulation of cell proliferation
GO:0009968; negative regulation of signal transduction
GO:0010906; regulation of glucose metabolic process
GO:0014912; negative regulation of smooth muscle cell migration
GO:0042981; regulation of apoptotic process
GO:0043065; positive regulation of apoptotic process
And 9 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0016942; insulin-like growth factor binding protein complex
GO:0042567; insulin-like growth factor ternary complex
GO:0070062; extracellular exosome
Function: GO:0001968; fibronectin binding
GO:0005515; protein binding
GO:0005520; insulin-like growth factor binding
GO:0008160; protein tyrosine phosphatase activator activity
GO:0031994; insulin-like growth factor I binding
GO:0031995; insulin-like growth factor II binding
GO:0046872; metal ion binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
IGF1R, IGF1, IGF2, PPARG
STRING interaction network
Protein-Protein network diagram for IGFBP3

Retrieve sequences for IGFBP3

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
igfbp3
Mus musculus
Igfbp3
Rattus norvegicus
Igfbp3

In other databases

LongevityMap
  • This gene is present as IGFBP3
CellAge
  • This gene is present as IGFBP3

Selected references

External links

EPD
HS_IGFBP3
ORF Accession
NM_000598
CDS Accession
NP_000589
OMIM
146732
HPRD
00899
Ensembl
IGFBP3
UniProt/Swiss-Prot
IBP3_HUMAN
GeneCards
IGFBP3
Entrez Gene
3486
UniGene
450230
GenAtlas
IGFBP3
Internet
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