GenAge entry for IL7 (Homo sapiens)

Gene name (HAGRID: 167)

HGNC symbol
IL7 
Aliases
IL-7 
Common name
interleukin 7 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

IL7 stimulates the proliferation of lymphoid progenitors. Mice without IL7 cease producing B lymphocyte after 7 weeks of age [772]. Declines with age in IL7 production have been associated with thymic atrophy [219]. Although IL7 could play a role age-related changes, such as ageing of the immune system, its role in human ageing is unknown.

Cytogenetic information

Cytogenetic band
8q12-q13
Location
78,732,772 bp to 78,805,523 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002360; T cell lineage commitment
GO:0006959; humoral immune response
GO:0007267; cell-cell signaling
GO:0008284; positive regulation of cell proliferation
GO:0009887; organ morphogenesis
GO:0010468; regulation of gene expression
GO:0030890; positive regulation of B cell proliferation
GO:0043066; negative regulation of apoptotic process
GO:0043086; negative regulation of catalytic activity
GO:0045453; bone resorption
GO:0045582; positive regulation of T cell differentiation
And 3 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
Function: GO:0005125; cytokine activity
GO:0005139; interleukin-7 receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
IL7R, IL2RG
STRING interaction network
Protein-Protein network diagram for IL7

Retrieve sequences for IL7

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Il7
Rattus norvegicus
Il7

In other databases

LongevityMap
  • This gene is present as IL7

Selected references

External links

EPD
ORF Accession
NM_000880
CDS Accession
NP_000871
OMIM
146660
HPRD
00892
Ensembl
IL7
UniProt/Swiss-Prot
IL7_HUMAN
GeneCards
IL7
Entrez Gene
3574
UniGene
591873
GenAtlas
IL7
Internet
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