GenAge entry for AR (Homo sapiens)

Gene name (HAGRID: 110)

HGNC symbol
AR 
Aliases
AIS; NR3C4; SMAX1; HUMARA; DHTR; SBMA 
Common name
androgen receptor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

AR is involved in transcriptional regulation and cellular proliferation and differentiation [576]. Disruption of AR in mice results in insulin (INS) and leptin (LEP) resistance, which suggests that AR may contribute to certain age-related diseases such as type 2 diabetes and cardiovascular disease [1331]. Its exact role in human ageing is unknown.

Cytogenetic information

Cytogenetic band
Xq12
Location
67,544,032 bp to 67,730,619 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001701; in utero embryonic development
GO:0003073; regulation of systemic arterial blood pressure
GO:0006351; transcription, DNA-templated
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006810; transport
GO:0007165; signal transduction
GO:0007267; cell-cell signaling
GO:0007283; spermatogenesis
GO:0007548; sex differentiation
GO:0008219; cell death
GO:0008283; cell proliferation
And 37 more GO terms
Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0030424; axon
GO:0030425; dendrite
GO:0043234; protein complex
Function: GO:0001085; RNA polymerase II transcription factor binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003700; sequence-specific DNA binding transcription factor activity
GO:0004879; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004882; androgen receptor activity
GO:0005102; receptor binding
GO:0005497; androgen binding
GO:0005515; protein binding
GO:0008013; beta-catenin binding
GO:0008134; transcription factor binding
And 8 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
ERCC2, STAT5B, STAT3, STAT5A, BRCA1, CREBBP, HSP90AA1, NR3C1, EP300, RB1, FOXO1, RELA, HDAC1, JUN, MED1, HMGB1, HBP1, SUMO1, ESR1, CTNNB1
STRING interaction network
Protein-Protein network diagram for AR

Retrieve sequences for AR

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ar
Mus musculus
Ar
Rattus norvegicus
Ar

In other databases

CellAge
  • This gene is present as AR

Selected references

External links

EPD
ORF Accession
NM_000044
CDS Accession
NP_000035
OMIM
313700
HPRD
02437
Ensembl
AR
UniProt/Swiss-Prot
ANDR_HUMAN
GeneCards
AR
Entrez Gene
367
UniGene
496240
GenAtlas
AR
Internet
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