GenAge entry for FGFR1 (Homo sapiens)

Gene name (HAGRID: 169)

HGNC symbol
FGFR1 
Aliases
H2; H3; H4; H5; CEK; FLG; BFGFR; N-SAM; CD331; FLT2; KAL2 
Common name
fibroblast growth factor receptor 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

FGFR1 is the receptor of the fibroblast growth factor. Mice with an attenuation of FGFR1 signalling develop diabetes with age and exhibit a decreased number of beta-cells [777]. Lower levels of FGFR1 in mice have also been related to craniofacial defects [778]. Mutations in the human FGFR1 gene have been associated with Pfeiffer [780] and Kallmann syndromes [779]. While FGFR1 could play a role in some age-related diseases, such as diabetes, its involvement in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
8p12
Location
38,411,138 bp to 38,468,834 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000165; MAPK cascade
GO:0001501; skeletal system development
GO:0001525; angiogenesis
GO:0001657; ureteric bud development
GO:0001701; in utero embryonic development
GO:0001759; organ induction
GO:0001764; neuron migration
GO:0002053; positive regulation of mesenchymal cell proliferation
GO:0002062; chondrocyte differentiation
GO:0006351; transcription, DNA-templated
And 44 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005634; nucleus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005887; integral to plasma membrane
GO:0016021; integral to membrane
GO:0016023; cytoplasmic membrane-bounded vesicle
Function: GO:0004713; protein tyrosine kinase activity
GO:0005007; fibroblast growth factor-activated receptor activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008201; heparin binding
GO:0017134; fibroblast growth factor binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, GRB2
STRING interaction network
Protein-Protein network diagram for FGFR1

Retrieve sequences for FGFR1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
fgfr1a
Mus musculus
Fgfr1
Rattus norvegicus
Fgfr1

In other databases

LongevityMap
  • This gene is present as FGFR1

Selected references

External links

EPD
ORF Accession
NM_000604
CDS Accession
NP_000595
OMIM
136350
HPRD
00634
Ensembl
FGFR1
UniProt/Swiss-Prot
FGFR1_HUMAN
GeneCards
FGFR1
Entrez Gene
2260
UniGene
264887
GenAtlas
FGFR1
Internet
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