GenAge entry for SERPINE1 (Homo sapiens)

Gene name (HAGRID: 301)

HGNC symbol
SERPINE1 
Aliases
PAI; PLANH1; PAI1 
Common name
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

PAI-1 (SERPINE1) is a serine protease inhibitor, which is elevated in Klotho (KL)-deficient mice. Klotho-deficient mice exhibit an accelerated aging-like phenotype including reduced lifespan, arteriosclerosis, and emphysema. PAI-1 deficiency retards the development of senescence and protects organ structure and function while prolonging the lifespan of the Klotho mutant mice [3484].

Cytogenetic information

Cytogenetic band
7q22.1
Location
101,127,089 bp to 101,139,266 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001300; chronological cell aging
GO:0001525; angiogenesis
GO:0002576; platelet degranulation
GO:0007623; circadian rhythm
GO:0010469; regulation of receptor activity
GO:0010757; negative regulation of plasminogen activation
GO:0010951; negative regulation of endopeptidase activity
GO:0014912; negative regulation of smooth muscle cell migration
GO:0030194; positive regulation of blood coagulation
GO:0030195; negative regulation of blood coagulation
GO:0030198; extracellular matrix organization
And 19 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005886; plasma membrane
GO:0031012; extracellular matrix
GO:0031093; platelet alpha granule lumen
GO:0070062; extracellular exosome
Function: GO:0002020; protease binding
GO:0004867; serine-type endopeptidase inhibitor activity
GO:0005102; receptor binding
GO:0005515; protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
PLAU, SERPINE1
STRING interaction network
Protein-Protein network diagram for SERPINE1

Retrieve sequences for SERPINE1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
srp-3
Danio rerio
serpine1
Mus musculus
Serpine1
Rattus norvegicus
Serpine1

In other databases

LongevityMap
CellAge

Selected references

External links

EPD
ORF Accession
NM_000602
CDS Accession
NP_000593
OMIM
173360
HPRD
01418
Ensembl
SERPINE1
UniProt/Swiss-Prot
A0A024QYT5_HUMAN
GeneCards
SERPINE1
Entrez Gene
5054
UniGene
414795
GenAtlas
SERPINE1
Internet
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