GenAge entry for GSK3B (Homo sapiens)

Gene name (HAGRID: 97)

HGNC symbol
GSK3B 
Aliases
 
Common name
glycogen synthase kinase 3 beta 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

Involved in development and metabolism, GSK3B may also play a role in cell survival. GSK3B null mice die at embryonic stages [522]. Adult overexpression of GSK3B in the brain of mice resulted in neurodegeneration, suggesting GSK3B could be related to Alzheimer's disease [1682]. Its part in human ageing, if any, is unknown.

Cytogenetic information

Cytogenetic band
3q13.3
Location
119,821,955 bp to 120,094,417 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000320; re-entry into mitotic cell cycle
GO:0001837; epithelial to mesenchymal transition
GO:0001954; positive regulation of cell-matrix adhesion
GO:0005977; glycogen metabolic process
GO:0006349; regulation of gene expression by genetic imprinting
GO:0006468; protein phosphorylation
GO:0006611; protein export from nucleus
GO:0006983; ER overload response
GO:0007212; dopamine receptor signaling pathway
GO:0007409; axonogenesis
GO:0007520; myoblast fusion
And 54 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005813; centrosome
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0014069; postsynaptic density
GO:0030426; growth cone
GO:0030529; intracellular ribonucleoprotein complex
GO:0030877; beta-catenin destruction complex
GO:0043025; neuronal cell body
And 4 more GO terms
Function: GO:0001085; RNA polymerase II transcription factor binding
GO:0002020; protease binding
GO:0002039; p53 binding
GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008013; beta-catenin binding
GO:0016301; kinase activity
GO:0019901; protein kinase binding
GO:0031625; ubiquitin protein ligase binding
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, PTPN11, PTPN1, AKT1, MYC, HSP90AA1, TOP2A, NFKB1, STK11, GSK3B, PRKCA, PRKDC, AR, FEN1, FOXO1, FOXM1, APP, PTK2, JUN, EEF1A1, CREB1, E2F1, MDM2, RELA, CEBPB, MTOR, CTNNB1, PSEN1, PPP1CA, MAPT, PPARGC1A, NFE2L2, RICTOR, NFE2L1
STRING interaction network
Protein-Protein network diagram for GSK3B

Retrieve sequences for GSK3B

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
gsk3b
Drosophila melanogaster
sgg
Mus musculus
Gsk3b
Rattus norvegicus
Gsk3b
Saccharomyces cerevisiae
MRK1

Selected references

External links

EPD
ORF Accession
NM_002093
CDS Accession
NP_002084
OMIM
605004
HPRD
05418
Ensembl
GSK3B
UniProt/Swiss-Prot
GSK3B_HUMAN
GeneCards
GSK3B
Entrez Gene
2932
UniGene
445733
GenAtlas
GSK3B
Internet
Search Google