GenAge entry for STAT5A (Homo sapiens)

Gene name (HAGRID: 23)

HGNC symbol
STAT5A 
Aliases
MGF; STAT5 
Common name
signal transducer and activator of transcription 5A 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

Like STAT5B, STAT5A is an important player in the activation of transcription and intracellular signalling. Mice with disrupted STAT5A and STAT5B, though short-lived due to numerous other deficiencies, exhibit phenotypes similar to those observed in GHR knockout mice in that they are 20%-40% smaller than controls with signs of disrupted GH1 functions such as lower IGF1 levels [1892]. Absence of Stat5 from pancreatic beta-cells in mice has no discernable impact on islet development and function in young animals, however, Stat5 appears to be an important component in beta-cell function in older mice [3666]. Its relation to other proteins that may be involved in ageing make STAT5A a promising subject of research in gerontology [266], though it is not known whether it plays a role in human ageing.

Cytogenetic information

Cytogenetic band
17q11.2
Location
42,287,547 bp to 42,311,942 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000255; allantoin metabolic process
GO:0001938; positive regulation of endothelial cell proliferation
GO:0006101; citrate metabolic process
GO:0006103; 2-oxoglutarate metabolic process
GO:0006105; succinate metabolic process
GO:0006107; oxaloacetate metabolic process
GO:0006351; transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006549; isoleucine metabolic process
GO:0006573; valine metabolic process
GO:0006600; creatine metabolic process
And 11 more GO terms
Cellular component: GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0004713; protein tyrosine kinase activity
GO:0004871; signal transducer activity
GO:0005515; protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GHR, SHC1, PTPN11, STAT5A, PTPN1, EGFR, INSR, PDGFRB, EPOR, BRCA1, BRCA2, NFKB1, EP300, HDAC1, JAK2, ESR1, PPARG, SQSTM1
STRING interaction network
Protein-Protein network diagram for STAT5A

Retrieve sequences for STAT5A

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
stat5.2
Mus musculus
Stat5a
Rattus norvegicus
Stat5a

Selected references

External links

EPD
ORF Accession
NM_003152
CDS Accession
NP_003143
OMIM
601511
HPRD
03301
Ensembl
STAT5A
UniProt/Swiss-Prot
STA5A_HUMAN
GeneCards
STAT5A
Entrez Gene
6776
UniGene
437058
GenAtlas
STAT5A
Internet
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