GenAge entry for NFKBIA (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 219)

HGNC symbol
NFKBIA 
Aliases
IKBA; MAD-3; IkappaBalpha; NFKBI 
Common name
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

NFKBIA inhibits NF-kappa-B by forming a complex with it, and may be involved in inflammation, apoptosis, differentiation, and growth. Downregulation of NFKBIA with age appears to occur in the rat liver [871]. Transgenic mice expressing dominant-negative IkB, and exhibiting functional inhibition of NF-kB signaling in endothelial cells, were protected from age-related insulin resistance and vascular senescence and, displayed a prolonged lifespan. In addition, the mice had also decreased oxidative stress markers, increased muscle blood flow, enhanced active-phase locomotor activity, and aortic upregulation of mitochondrial sirtuin-related proteins [2115]. Whether NFKBIA plays a role in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
14q13
Location
35,401,510 bp to 35,404,754 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000060; protein import into nucleus, translocation
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006915; apoptotic process
GO:0007253; cytoplasmic sequestering of NF-kappaB
GO:0010745; negative regulation of macrophage derived foam cell differentiation
GO:0010875; positive regulation of cholesterol efflux
GO:0010888; negative regulation of lipid storage
GO:0016032; viral process
GO:0031663; lipopolysaccharide-mediated signaling pathway
GO:0032088; negative regulation of NF-kappaB transcription factor activity
GO:0032270; positive regulation of cellular protein metabolic process
And 22 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0033256; I-kappaB/NF-kappaB complex
Function: GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008139; nuclear localization sequence binding
GO:0019899; enzyme binding
GO:0031072; heat shock protein binding
GO:0031625; ubiquitin protein ligase binding
GO:0032403; protein complex binding
GO:0042802; identical protein binding
GO:0051059; NF-kappaB binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, NFKB2, HDAC3, NCOR1, PIN1, VCP, ABL1, NFKB1, UBE2I, TNF, PRKCA, RELA, HDAC1, MAPK14, PIK3R1, HDAC2, HOXB7, CLU, MTOR, NCOR2, IKBKB
STRING interaction network
Protein-Protein network diagram for NFKBIA

Retrieve sequences for NFKBIA

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
nfkbiaa
Drosophila melanogaster
cact
Mus musculus
Nfkbia
Rattus norvegicus
Nfkbia

In other databases

GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Nfkbia

Selected references

External links

EPD
HS_NFKBIA
ORF Accession
NM_020529
CDS Accession
NP_065390
OMIM
164008
HPRD
01235
Ensembl
NFKBIA
UniProt/Swiss-Prot
IKBA_HUMAN
GeneCards
NFKBIA
Entrez Gene
4792
UniGene
81328
GenAtlas
NFKBIA
Internet
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