GenAge entry for CCNA2 (Homo sapiens)

Gene name (HAGRID: 177)

HGNC symbol
CCNA2 
Aliases
CCNA; CCN1 
Common name
cyclin A2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

Important cyclin involved in cell cycle control [794], CCNA2 could be a downstream target of pathways related to senescence and ageing. CCNA2's role in human ageing is unknown.

Cytogenetic information

Cytogenetic band
4q27
Location
121,816,444 bp to 121,823,933 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000079; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086; G2/M transition of mitotic cell cycle
GO:0007067; mitotic nuclear division
GO:0007265; Ras protein signal transduction
GO:0010389; regulation of G2/M transition of mitotic cell cycle
GO:0016032; viral process
GO:0031100; animal organ regeneration
GO:0033762; response to glucagon
GO:0036120; cellular response to platelet-derived growth factor stimulus
GO:0044320; cellular response to leptin stimulus
GO:0045893; positive regulation of transcription, DNA-templated
And 11 more GO terms
Cellular component: GO:0001939; female pronucleus
GO:0001940; male pronucleus
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005794; Golgi apparatus
GO:0097124; cyclin A2-CDK2 complex
Function: GO:0005515; protein binding
GO:0019901; protein kinase binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, E2F1, BRCA1, CREBBP, RPA1, BRCA2, EP300, PCNA, FEN1, RB1, SP1, CCNA2, BUB1B, CDK1, POLA1, HDAC2, CTNNB1, TP73, CDKN1A, CDK7
STRING interaction network
Protein-Protein network diagram for CCNA2

Retrieve sequences for CCNA2

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
ZK507.6
Drosophila melanogaster
CycA
Mus musculus
Ccna2
Rattus norvegicus
Ccna2

Selected references

External links

EPD
ORF Accession
NM_001237
CDS Accession
NP_001228
OMIM
123835
HPRD
00453
Ensembl
CCNA2
UniProt/Swiss-Prot
CCNA2_HUMAN
GeneCards
CCNA2
Entrez Gene
890
UniGene
58974
GenAtlas
CCNA2
Internet
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