GenAge entry for RELA (Homo sapiens)

Gene name (HAGRID: 143)

HGNC symbol
RELA 
Aliases
p65; NFKB3 
Common name
v-rel avian reticuloendotheliosis viral oncogene homolog A 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Also known as NFKB3, RELA is a component of the NF-kappa-B complex, involved in oxidative pathways and a myriad of other processes. Its role in ageing is unclear, but the NF-kappa-B complex appears to be important in age-related changes in inflammation and maybe in other age-related processes too [260]. In addition, age-related changes in NF-kappa-B have been reported in numerous tissues [261]. Mice without RELA die at embryonic stages [712].

Cytogenetic information

Cytogenetic band
11q13
Location
65,653,596 bp to 65,662,972 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001889; liver development
GO:0001942; hair follicle development
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006117; acetaldehyde metabolic process
GO:0006366; transcription from RNA polymerase II promoter
GO:0006954; inflammatory response
GO:0006968; cellular defense response
GO:0007568; aging
GO:0008284; positive regulation of cell proliferation
GO:0009887; animal organ morphogenesis
And 44 more GO terms
Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0033256; I-kappaB/NF-kappaB complex
GO:0071159; NF-kappaB complex
Function: GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000983; transcription factor activity, RNA polymerase II core promoter sequence-specific
GO:0001046; core promoter sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001205; transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
And 20 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, TERT, ATM, NFKB2, STAT3, MYC, FOS, PPARA, HDAC3, PARP1, BRCA1, PIN1, CREBBP, HIF1A, EGR1, NFKB1, EP300, PML, GSK3B, PRKDC, AR, HSPA8, SIRT1, HDAC1, HSPA1A, MAPK14, SP1, JUN, HMGB1, TFAP2A, TBP, HDAC2, MDM2, TAF1, RELA, NR3C1, CEBPB, ESR1, NFKBIA, CDKN2A, TP63, SIRT6, STUB1, PPARGC1A, PPARG, NCOR2, IKBKB
STRING interaction network
Protein-Protein network diagram for RELA

Retrieve sequences for RELA

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
rela
Drosophila melanogaster
Dif
Mus musculus
Rela
Rattus norvegicus
Rela

Selected references

External links

EPD
HS_RELA
ORF Accession
NM_021975
CDS Accession
NP_068810
OMIM
164014
HPRD
01241
Ensembl
RELA
UniProt/Swiss-Prot
TF65_HUMAN
GeneCards
RELA
Entrez Gene
5970
UniGene
502875
GenAtlas
RELA
Internet
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