GenAge entry for PIN1 (Homo sapiens)

Gene name (HAGRID: 62)

HGNC symbol
PIN1 
Aliases
dod 
Common name
peptidylprolyl cis/trans isomerase, NIMA-interacting 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

Important for the regulation of mitosis and cell cycle progression, PIN1 is critical for TP53 function [424]. Some results indicate that PIN1 plays a role in protecting against neurodegenerative diseases [421], and PIN1 regulates APP processing, suggesting a possible role in Alzheimer's disease [1621]. Although PIN1 has not been directly related to ageing, it is a promising avenue of research, at least in relation to neurodegeneration.

Cytogenetic information

Cytogenetic band
19p13
Location
9,835,207 bp to 9,849,689 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000413; protein peptidyl-prolyl isomerization
GO:0001934; positive regulation of protein phosphorylation
GO:0007049; cell cycle
GO:0007088; regulation of mitotic nuclear division
GO:0030182; neuron differentiation
GO:0030512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032091; negative regulation of protein binding
GO:0032465; regulation of cytokinesis
GO:0032480; negative regulation of type I interferon production
GO:0035307; positive regulation of protein dephosphorylation
GO:0042177; negative regulation of protein catabolic process
And 15 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0016607; nuclear speck
GO:0030496; midbody
GO:0043005; neuron projection
Function: GO:0003755; peptidyl-prolyl cis-trans isomerase activity
GO:0003774; motor activity
GO:0005515; protein binding
GO:0008013; beta-catenin binding
GO:0031434; mitogen-activated protein kinase kinase binding
GO:0032794; GTPase activating protein binding
GO:0050815; phosphoserine binding
GO:0050816; phosphothreonine binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, HDAC3, MYC, ERBB2, BCL2, TOP2A, EP300, PML, XRCC6, SOD1, RELA, HDAC1, SP1, JUN, MED1, FOXO4, MAPT, LEPR, NFKBIA, CTNNB1, GPX4, PPARG, TP73
STRING interaction network
Protein-Protein network diagram for PIN1

Retrieve sequences for PIN1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
pinn-1
Danio rerio
pin1
Drosophila melanogaster
dod
Mus musculus
Pin1
Rattus norvegicus
LOC364561
Saccharomyces cerevisiae
ESS1
Schizosaccharomyces pombe
pin1

Selected references

External links

EPD
HS_PIN1
ORF Accession
NM_006221
CDS Accession
NP_006212
OMIM
601052
HPRD
03031
Ensembl
PIN1
UniProt/Swiss-Prot
PIN1_HUMAN
GeneCards
PIN1
Entrez Gene
5300
UniGene
465849
GenAtlas
PIN1
Internet
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