GenAge entry for MAPK9 (Homo sapiens)

Gene name (HAGRID: 174)

HGNC symbol
MAPK9 
Aliases
JNK2; p54a; SAPK; PRKM9 
Common name
mitogen-activated protein kinase 9 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

Also called JNK2, MAPK9 encodes many transcripts and is an important player in stress response. In invertebrates, there is evidence linking JNK signalling to ageing. Fruit flies with mutations that augment JNK signalling live longer [212]. Overexpression of JNK in roundworms also increases lifespan [60]. Mice without MAPK8 and MAPK9 die at embryonic stages. MAPK9-null mice develop normally [786], but are defective in peripheral T-cell activation [1721]. Further research is needed to determine whether MAPK9 is related to human ageing.

Cytogenetic information

Cytogenetic band
5q35
Location
180,233,595 bp to 180,292,071 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006468; protein phosphorylation
GO:0006950; response to stress
GO:0007254; JNK cascade
GO:0007258; JUN phosphorylation
GO:0010628; positive regulation of gene expression
GO:0010744; positive regulation of macrophage derived foam cell differentiation
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0042752; regulation of circadian rhythm
GO:0046686; response to cadmium ion
GO:0048511; rhythmic process
GO:0051090; regulation of sequence-specific DNA binding transcription factor activity
And 3 more GO terms
Cellular component: GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
Function: GO:0004705; JUN kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008134; transcription factor binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, AKT1, EGFR, JUND, FOS, PRKDC, GRB2, HDAC1, MAPK8, JUN, MAPK9, ATF2, CLU, CTNNB1, CSNK1E, CDC42, NFE2L2
STRING interaction network
Protein-Protein network diagram for MAPK9

Retrieve sequences for MAPK9

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
jnk-1
Danio rerio
mapk9
Drosophila melanogaster
bsk
Mus musculus
Mapk9
Rattus norvegicus
Mapk9

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as jnk-1
  • A homolog of this gene for Drosophila melanogaster is present as bsk

Selected references

External links

EPD
ORF Accession
NM_002752
CDS Accession
NP_002743
OMIM
602896
HPRD
04206
Ensembl
MAPK9
UniProt/Swiss-Prot
MK09_HUMAN
GeneCards
MAPK9
Entrez Gene
5601
UniGene
654461
GenAtlas
MAPK9
Internet
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