The GenDR Database of Dietary Restriction-Related Genes
Dietary restriction (DR), limiting nutrient intake from diet without causing malnutrition , retards age-related degeneration and extends lifespan in multiple organisms. DR induces multiple changes, yet its underlying mechanisms remain poorly understood. To facilitate research on the genetic and molecular mechanisms of DR-induced life-extension, we developed GenDR, a database of genes associated with DR. GenDR includes two datasets: 1) genes inferred from experiments in model organisms in which genetic manipulations cancel out or disrupt the life-extending effects of DR; 2) genes robustly altered due to DR, derived from a meta-analysis of microarray DR studies in mammals. An analysis of the gene network of DR has also been performed using GenDR.
Understanding the genetic basis of DR is of great importance not only to the biology of ageing but to understand how diet can influence ageing, longevity, health and age-related diseases. Pharmaceutical interventions that target DR-associated genes are also an emerging area with huge potential. For more information on DR and its potential, please refer to a recent review.
Search Gene Manipulations
View by Organism
- Caenorhabditis elegans
- Drosophila melanogaster
- Mus musculus
- Saccharomyces cerevisiae
- Schizosaccharomyces pombe
Download human homologs
You can download human homologs for all of the genes in GenDR.
View as a matrix
You can also view the genes and their homologs in the form of a matrix.
Search Gene Expression
To search for a particular gene please type your search query below. You can use as query the gene's symbol or its name. These are mammalian gene expression signatures but the data has been mapped to mouse genes. The search is case insensitive.
You can browse or search the literature in GenDR:
You can dowload the GenDR gene manipulations database as a tab-delimited ASCII dataset.
The DR gene expression signatures are available as an excel file.