GenAge entry for TOP2A (Homo sapiens)

Gene name (HAGRID: 80)

HGNC symbol
TOP2A 
Aliases
TOP2 
Common name
topoisomerase (DNA) II alpha 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Topoisomerases regulate the topological states of DNA [483]. Though no direct interaction has been reported, TOP2A has been indirectly linked to WRN [61] and ATM [482]. TOP2A has also been suggested as an important player in neuron proliferation [483]. Because TOP2A has been associated with several DNA metabolism proteins thought to play a role in ageing, it is possible that TOP2A itself is involved in human ageing, though further studies are necessary to confirm this hypothesis.

Cytogenetic information

Cytogenetic band
17q21-q22
Location
40,388,521 bp to 40,417,950 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000712; resolution of meiotic recombination intermediates
GO:0000819; sister chromatid segregation
GO:0002244; hematopoietic progenitor cell differentiation
GO:0006265; DNA topological change
GO:0006266; DNA ligation
GO:0006268; DNA unwinding involved in DNA replication
GO:0006312; mitotic recombination
GO:0006974; cellular response to DNA damage stimulus
GO:0007059; chromosome segregation
GO:0016925; protein sumoylation
GO:0030263; apoptotic chromosome condensation
And 9 more GO terms
Cellular component: GO:0000228; nuclear chromosome
GO:0000793; condensed chromosome
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005814; centriole
GO:0009295; nucleoid
GO:0009330; DNA topoisomerase complex (ATP-hydrolyzing)
GO:0019035; viral integration complex
GO:0043234; protein complex
Function: GO:0000287; magnesium ion binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003918; DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080; protein kinase C binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0008094; DNA-dependent ATPase activity
GO:0008144; drug binding
GO:0008301; DNA binding, bending
And 7 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, LMNA, MYC, BRCA1, PIN1, RPA1, BLM, TOP2B, TOP1, UBE2I, GSK3B, PRKCA, XRCC5, TERF2, RB1, HDAC1, JUN, BMI1, HDAC2, ESR1, CTNNB1
STRING interaction network
Protein-Protein network diagram for TOP2A

Retrieve sequences for TOP2A

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Top2a
Rattus norvegicus
Top2a

Selected references

External links

EPD
ORF Accession
NM_001067
CDS Accession
NP_001058
OMIM
126430
HPRD
00536
Ensembl
TOP2A
UniProt/Swiss-Prot
TOP2A_HUMAN
GeneCards
TOP2A
Entrez Gene
7153
UniGene
156346
GenAtlas
TOP2A
Internet
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