GenAge entry for HSPA1B (Homo sapiens)

Gene name (HAGRID: 161)

HGNC symbol
HSPA1B 
Aliases
HSP70-2 
Common name
heat shock 70kDa protein 1B 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

HSPA1B is involved in stress response and recognition of abnormal proteins, but also in signalling cascades. Results from invertebrates have suggested that heat-shock proteins, such as hsp70, a homologue of HSPA1B, are involved in ageing [210]. Whether HSPA1B is involved in human ageing is unknown.

Cytogenetic information

Cytogenetic band
6p21.3
Location
3,075,514 bp to 3,078,033 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006402; mRNA catabolic process
GO:0006986; response to unfolded protein
GO:0008285; negative regulation of cell proliferation
GO:0010467; gene expression
GO:0016070; RNA metabolic process
GO:0016071; mRNA metabolic process
GO:0030308; negative regulation of cell growth
GO:0042026; protein refolding
GO:0043066; negative regulation of apoptotic process
GO:0045648; positive regulation of erythrocyte differentiation
GO:0090084; negative regulation of inclusion body assembly
And 2 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0008180; COP9 signalosome
GO:0016234; inclusion body
GO:0016235; aggresome
GO:0016607; nuclear speck
GO:0030529; ribonucleoprotein complex
GO:0048471; perinuclear region of cytoplasm
And 1 more GO terms
Function: GO:0001618; virus receptor activity
GO:0003725; double-stranded RNA binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0031625; ubiquitin protein ligase binding
GO:0044183; protein binding involved in protein folding
GO:0047485; protein N-terminus binding
GO:0051082; unfolded protein binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for HSPA1B

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
hsp-1
Danio rerio
hsp70l
Mus musculus
Hspa1b
Rattus norvegicus
Hspa1a

In other databases

LongevityMap
  • This gene is present as HSPA1B

Selected references

External links

EPD
ORF Accession
NM_005346
CDS Accession
NP_005337
OMIM
603012
HPRD
06784
Ensembl
HSPA1B
UniProt/Swiss-Prot
HSP71_HUMAN
GeneCards
HSPA1B
Entrez Gene
3304
UniGene
274402
GenAtlas
HSPA1B
Internet
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