GenAge entry for HSPA1B (Homo sapiens)

Gene name (HAGRID: 161)

HGNC symbol
HSPA1B 
Aliases
HSP70-2 
Common name
heat shock 70kDa protein 1B 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

HSPA1B is involved in stress response and recognition of abnormal proteins, but also in signalling cascades. Results from invertebrates have suggested that heat-shock proteins, such as hsp70, a homologue of HSPA1B, are involved in ageing [210]. Whether HSPA1B is involved in human ageing is unknown.

Cytogenetic information

Cytogenetic band
6p21.3
Location
3,075,514 bp to 3,078,033 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0010628; positive regulation of gene expression
GO:0010941; regulation of cell death
GO:0031396; regulation of protein ubiquitination
GO:0031397; negative regulation of protein ubiquitination
GO:0032757; positive regulation of interleukin-8 production
GO:0034599; cellular response to oxidative stress
GO:0034605; cellular response to heat
GO:0042026; protein refolding
GO:0046034; ATP metabolic process
GO:0046718; viral entry into host cell
GO:0050821; protein stabilization
And 9 more GO terms
Cellular component: GO:0000151; ubiquitin ligase complex
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005814; centriole
GO:0005829; cytosol
GO:0005925; focal adhesion
GO:0016234; inclusion body
GO:0048471; perinuclear region of cytoplasm
GO:0072562; blood microparticle
Function: GO:0001618; virus receptor activity
GO:0001664; G-protein coupled receptor binding
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016887; ATPase activity
GO:0019899; enzyme binding
GO:0031072; heat shock protein binding
GO:0031625; ubiquitin protein ligase binding
GO:0042623; ATPase activity, coupled
GO:0042826; histone deacetylase binding
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, EGFR, HSP90AA1, GRB2, YWHAZ, CTNNB1, STUB1
STRING interaction network
Protein-Protein network diagram for HSPA1B

Retrieve sequences for HSPA1B

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
hsp-1
Danio rerio
hsp70l
Mus musculus
Hspa1b
Rattus norvegicus
Hspa1a

In other databases

LongevityMap
  • This gene is present as HSPA1B

Selected references

External links

EPD
ORF Accession
NM_005346
CDS Accession
NP_005337
OMIM
603012
HPRD
06784
Ensembl
HSPA1B
UniProt/Swiss-Prot
HSP71_HUMAN
GeneCards
HSPA1B
Entrez Gene
3304
UniGene
274402
GenAtlas
HSPA1B
Internet
Search Google