GenAge entry for EP300 (Homo sapiens)

Gene name (HAGRID: 94)

HGNC symbol
EP300 
Aliases
p300; KAT3B 
Common name
E1A binding protein p300 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

EP300 is a transcriptional coactivator that mediates many transcriptional events including DNA repair. It also acts as a histone acetyltransferase to regulate transcription through chromatin structural changes [514]. EP300 activity is attenuated in ageing mice [426]. Because EP300 has been associated with several other proteins that may be involved in ageing, such as WRN [511], EP300 might somehow impact on human ageing.

Cytogenetic information

Cytogenetic band
22q13.2
Location
41,092,610 bp to 41,180,077 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001666; response to hypoxia
GO:0001756; somitogenesis
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0006473; protein acetylation
GO:0006475; internal protein amino acid acetylation
GO:0006915; apoptotic process
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
And 37 more GO terms
Cellular component: GO:0000123; histone acetyltransferase complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
Function: GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001047; core promoter binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0002039; p53 binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003684; damaged DNA binding
GO:0003713; transcription coactivator activity
GO:0004402; histone acetyltransferase activity
GO:0004468; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
And 14 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ERCC8, STAT3, STAT5A, AKT1, MYC, FOS, PRKCD, PPARA, HDAC3, PARP1, BRCA1, PIN1, CREBBP, HIF1A, NCOR1, EGR1, NFKB1, UBE2I, EP300, PRKCA, EEF2, TERF1, PRKDC, AR, PCNA, FEN1, TERF2, XRCC6, RB1, GRB2, FOXO3, FOXO1, XPA, RECQL4, SIRT1, HDAC1, MAPK8, YWHAZ, MAPK14, SP1, JUN, CCNA2, MAP3K5, PIK3R1, BMI1, EEF1A1, TFAP2A, CREB1, ATF2, TBP, APEX1, HBP1, PTGS2, CDK1, E2F1, MAX, MDM2, DDIT3, RELA, TCF3, JUND, NBN, NR3C1, CEBPB, ESR1, CTNNB1, MAPT, TP63, POLB, ATR, PCK1, ARNTL, CLOCK, PPARGC1A, PPARG, TP53BP1, NCOR2, TP73, CDKN1A, CTF1
STRING interaction network
Protein-Protein network diagram for EP300

Retrieve sequences for EP300

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ep300a
Mus musculus
Ep300

Selected references

External links

EPD
ORF Accession
NM_001429
CDS Accession
NP_001420
OMIM
602700
HPRD
04078
Ensembl
EP300
UniProt/Swiss-Prot
EP300_HUMAN
GeneCards
EP300
Entrez Gene
2033
UniGene
517517
GenAtlas
EP300
Internet
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