GenAge entry for PPM1D (Homo sapiens)

Gene name (HAGRID: 246)

HGNC symbol
PPM1D 
Aliases
Wip1; PP2C-DELTA 
Common name
protein phosphatase, Mg2+/Mn2+ dependent, 1D 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

PPM1D is upregulated by p53 in response to a number of stresses, such as DNA damage, and behaves as an oncogene. PPM1D-null males, but interestingly not females, showed reduced longevity and body weight and some signs of premature ageing. IGF1 levels were higher in PPM1D-null males until about one year of age yet then declined faster than in controls. PPM1D-null mice were cancer resistant and had an augmented stress response following DNA damage [1837].

Cytogenetic information

Cytogenetic band
17q23.2
Location
60,600,183 bp to 60,666,279 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000086; G2/M transition of mitotic cell cycle
GO:0006470; protein dephosphorylation
GO:0008285; negative regulation of cell proliferation
GO:0009314; response to radiation
GO:0009617; response to bacterium
GO:0035970; peptidyl-threonine dephosphorylation
Cellular component: GO:0005634; nucleus
Function: GO:0004722; protein serine/threonine phosphatase activity
GO:0005515; protein binding
GO:0046872; metal ion binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for PPM1D

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ppm1db
Mus musculus
Ppm1d
Rattus norvegicus
Ppm1d

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Ppm1d
CellAge
  • This gene is present as PPM1D

Selected references

External links

EPD
ORF Accession
NM_003620
CDS Accession
NP_003611
OMIM
605100
HPRD
05482
Ensembl
PPM1D
UniProt/Swiss-Prot
PPM1D_HUMAN
GeneCards
PPM1D
Entrez Gene
8493
UniGene
591184
GenAtlas
PPM1D
Internet
Search Google