GenAge entry for PRKDC (Homo sapiens)

Gene name (HAGRID: 106)

HGNC symbol
PRKDC 
Aliases
DNPK1; p350; DNAPK; XRCC7; DNA-PKcs; HYRC; HYRC1 
Common name
protein kinase, DNA-activated, catalytic polypeptide 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

PRKDC is involved in DNA repair and may modulate transcription [554]. Evidence also suggests PRKDC may be involved in telomere biology [557]. Because PRKDC has been associated with many pathways with genes likely to be involved in human ageing, such as WRN [558], it is possible that PRKDC itself is involved in human ageing, though further research is necessary to investigate this hypothesis.

Cytogenetic information

Cytogenetic band
8q11
Location
47,773,108 bp to 47,960,183 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001756; somitogenesis
GO:0001933; negative regulation of protein phosphorylation
GO:0002326; B cell lineage commitment
GO:0002328; pro-B cell differentiation
GO:0002360; T cell lineage commitment
GO:0002638; negative regulation of immunoglobulin production
GO:0002684; positive regulation of immune system process
GO:0006302; double-strand break repair
GO:0006303; double-strand break repair via nonhomologous end joining
GO:0006464; cellular protein modification process
GO:0007420; brain development
And 29 more GO terms
Cellular component: GO:0000784; nuclear chromosome, telomeric region
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005730; nucleolus
GO:0005829; cytosol
GO:0005958; DNA-dependent protein kinase-DNA ligase 4 complex
GO:0016020; membrane
GO:0031012; extracellular matrix
GO:0070419; nonhomologous end joining complex
Function: GO:0003690; double-stranded DNA binding
GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004677; DNA-dependent protein kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0044822; poly(A) RNA binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, ATM, WRN, LMNA, AKT1, MYC, EGFR, HDAC3, PARP1, BRCA1, RPA1, HSP90AA1, ABL1, UBE2I, EP300, GSK3B, TERF1, PRKDC, AR, XRCC5, PCNA, XRCC6, HSPA8, EMD, HSF1, XPA, PRDX1, MAPK8, SP1, JUN, MAPK9, BMI1, RELA, NBN, H2AFX, HOXB7, NR3C1, ESR1, SIRT6, MLH1, CHEK2, SIRT7, GSK3A, IKBKB
STRING interaction network
Protein-Protein network diagram for PRKDC

Retrieve sequences for PRKDC

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
wu:fa96e12
Mus musculus
Prkdc
Rattus norvegicus
Prkdc

In other databases

LongevityMap
  • This gene is present as PRKDC

Selected references

External links

EPD
ORF Accession
NM_006904
CDS Accession
NP_008835
OMIM
600899
HPRD
02941
Ensembl
PRKDC
UniProt/Swiss-Prot
PRKDC_HUMAN
GeneCards
PRKDC
Entrez Gene
5591
UniGene
700597
GenAtlas
PRKDC
Internet
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