GenAge entry for APP (Homo sapiens)

Gene name (HAGRID: 137)

HGNC symbol
APP 
Aliases
AD1 
Common name
amyloid beta (A4) precursor protein 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

APP has different functions. It is a cell surface receptor, interacts with many other proteins, and may regulate neurite growth. Clearly, APP is an important player in Alzheimer's disease [695], though it is not known whether it is related to other aspects of ageing.

Cytogenetic information

Cytogenetic band
21q21.3
Location
25,880,550 bp to 26,170,820 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001967; suckling behavior
GO:0002576; platelet degranulation
GO:0006378; mRNA polyadenylation
GO:0006417; regulation of translation
GO:0006468; protein phosphorylation
GO:0006878; cellular copper ion homeostasis
GO:0006897; endocytosis
GO:0006979; response to oxidative stress
GO:0007155; cell adhesion
GO:0007176; regulation of epidermal growth factor-activated receptor activity
GO:0007219; Notch signaling pathway
And 37 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005641; nuclear envelope lumen
GO:0005737; cytoplasm
GO:0005768; endosome
GO:0005790; smooth endoplasmic reticulum
GO:0005791; rough endoplasmic reticulum
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
And 27 more GO terms
Function: GO:0003677; DNA binding
GO:0004867; serine-type endopeptidase inhibitor activity
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0008201; heparin binding
GO:0016504; peptidase activator activity
GO:0019899; enzyme binding
GO:0042802; identical protein binding
GO:0046914; transition metal ion binding
GO:0051425; PTB domain binding
GO:0070851; growth factor receptor binding
And 1 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, IGF1R, STAT5B, INS, IRS1, AKT1, MYC, EGFR, FOS, PRKCD, HSP90AA1, TOP1, UBE2I, TGFB1, STK11, GSK3B, CAT, FEN1, HSPA8, SOD2, LRP2, UCHL1, APP, A2M, ATP5O, ERCC1, HSPD1, MAPK8, YWHAZ, PTK2, IL7, JUN, HMGB2, MAP3K5, BDNF, ATF2, APEX1, PTGS2, HSPA9, MXD1, MDM2, UBB, MXI1, HOXB7, HOXC4, HELLS, CLU, CTNNB1, PSEN1, MAPT, PDPK1, CSNK1E, STUB1, CHEK2, PCK1, PPARG, CISD2, SIRT7, CDKN1A, CDKN2B, CDK7, CTF1, TRAP1
STRING interaction network
Protein-Protein network diagram for APP

Retrieve sequences for APP

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
appb
Mus musculus
App
Rattus norvegicus
App

Selected references

External links

EPD
HS_APP
ORF Accession
NM_000484
CDS Accession
NP_000475
OMIM
104760
HPRD
00100
Ensembl
APP
UniProt/Swiss-Prot
A4_HUMAN
GeneCards
APP
Entrez Gene
351
UniGene
434980
GenAtlas
APP
Internet
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