GenAge entry for DLL3 (Homo sapiens)

Gene name (HAGRID: 225)

HGNC symbol
DLL3 
Aliases
SCDO1 
Common name
delta-like 3 (Drosophila) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

DLL3 is a member of the Notch pathway involved in development. In mice, Notch signalling, including DLL3, has been linked to regeneration in the liver [1385]. DLL3 has also been linked to development and neurogenesis. Mutations in DLL3 have been associated with developmental defects, but not ageing. The Pudgy (pu) mice phenotype of severe vertebral and rib deformities is caused by a mutation in DLL3 [1388]. Mutations in the human DDL3 gene cause axial skeletal defects [1390]. It is unclear whether DLL3 plays a role in human ageing but it could be part of age-related changes in regenerative ability [1386].

Cytogenetic information

Cytogenetic band
19q13
Location
44,681,426 bp to 44,690,948 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser

Protein information

Gene Ontology
Process: GO:0001501; skeletal system development
GO:0001756; somitogenesis
GO:0007219; Notch signaling pathway
GO:0007386; compartment pattern specification
GO:0048339; paraxial mesoderm development
GO:0050768; negative regulation of neurogenesis
Cellular component: GO:0016021; integral to membrane
Function: GO:0005112; Notch binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for DLL3

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Dll3
Rattus norvegicus
Dll3

Selected references

External links

EPD
ORF Accession
NM_016941
CDS Accession
NP_058637
OMIM
602768
HPRD
04140
Ensembl
DLL3
UniProt/Swiss-Prot
DLL3_HUMAN
GeneCards
DLL3
Entrez Gene
10683
UniGene
127792
GenAtlas
DLL3
Internet
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