GenAge entry for EGR1 (Homo sapiens)

Gene name (HAGRID: 76)

HGNC symbol
EGR1 
Aliases
TIS8; G0S30; NGFI-A; KROX-24; ZIF-268; AT225; ZNF225 
Common name
early growth response 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

An important regulator of the cell cycle, EGR1 has been suggested to act upstream of ageing-related genes such as TP53 [163]. It also appears to be pro-apoptotic [466]. EGR1's role in ageing is unknown, but it might be part of its signalling cascade. Further studies are necessary to establish whether EGR1 is a factor in human ageing.

Cytogenetic information

Cytogenetic band
5q31.1
Location
138,465,492 bp to 138,469,315 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001666; response to hypoxia
GO:0002931; response to ischemia
GO:0006366; transcription from RNA polymerase II promoter
GO:0009749; response to glucose
GO:0030217; T cell differentiation
GO:0030509; BMP signaling pathway
GO:0032868; response to insulin
GO:0033233; regulation of protein sumoylation
GO:0035914; skeletal muscle cell differentiation
GO:0042981; regulation of apoptotic process
And 18 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
Function: GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0010385; double-stranded methylated DNA binding
GO:0035035; histone acetyltransferase binding
GO:0043565; sequence-specific DNA binding
GO:0044729; hemi-methylated DNA-binding
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, JUND, PTEN, CREBBP, CEBPB, EP300, RELA, SP1, MDM2, CTNNB1, CDKN2A
STRING interaction network
Protein-Protein network diagram for EGR1

Retrieve sequences for EGR1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
egrh-2
Danio rerio
egr1
Mus musculus
Egr1
Rattus norvegicus
Egr1
Schizosaccharomyces pombe
prz1

Selected references

External links

EPD
ORF Accession
NM_001964
CDS Accession
NP_001955
OMIM
128990
HPRD
00549
Ensembl
EGR1
UniProt/Swiss-Prot
EGR1_HUMAN
GeneCards
EGR1
Entrez Gene
1958
UniGene
326035
GenAtlas
EGR1
Internet
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