GenAge entry for HRAS (Homo sapiens)

Gene name (HAGRID: 38)

HGNC symbol
HRAS 
Aliases
HRAS1 
Common name
Harvey rat sarcoma viral oncogene homolog 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

HRAS is a member of the RAS family of oncogenes and probably plays a role in cell growth and differentiation. In roundworms, the RAS pathway has been shown to influence development and ageing in conjunction with INS/IGF1 [1517], and RAS signalling has been associated with brain degeneration in fruit flies [345]. Although HRAS is involved in cancer and cellular senescence [339], its role in human ageing is unknown.

Cytogenetic information

Cytogenetic band
11p15.5
Location
532,242 bp to 535,550 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0000186; activation of MAPKK activity
GO:0001934; positive regulation of protein phosphorylation
GO:0006897; endocytosis
GO:0006935; chemotaxis
GO:0007050; cell cycle arrest
GO:0007093; mitotic cell cycle checkpoint
GO:0007165; signal transduction
GO:0007166; cell surface receptor signaling pathway
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0007264; small GTPase mediated signal transduction
And 41 more GO terms
Cellular component: GO:0000139; Golgi membrane
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0048471; perinuclear region of cytoplasm
Function: GO:0003924; GTPase activity
GO:0005515; protein binding
GO:0005525; GTP binding
GO:0008022; protein C-terminus binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
INSR, BCL2, PML, GRB2, MAPK8, PIK3R1, TP73
STRING interaction network
Protein-Protein network diagram for HRAS

Retrieve sequences for HRAS

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
hrasb
Mus musculus
Hras1
Rattus norvegicus
Hras1

In other databases

LongevityMap
  • This gene is present as HRAS
CellAge
  • This gene is present as HRAS

Selected references

External links

EPD
HS_HRAS_3
ORF Accession
NM_005343
CDS Accession
NP_005334
OMIM
190020
HPRD
01813
Ensembl
HRAS
UniProt/Swiss-Prot
RASH_HUMAN
GeneCards
HRAS
Entrez Gene
3265
UniGene
37003
GenAtlas
HRAS
Internet
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