GenAge entry for IGF1 (Homo sapiens)

Gene name (HAGRID: 28)

HGNC symbol
IGF1 
Aliases
IGF1A; IGFI; IGF-I 
Common name
insulin-like growth factor 1 (somatomedin C) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

IGF1 is a hormone that stimulates growth and mediates many of the actions of GH1. Like GH1, its circulating levels decline with age in humans. The GH1/IGFI axis is considered a possible player in the ageing process of several model organisms, including rodents [286].

IGF1 null mice show growth deficiency and usually are not viable, though some can reach adulthood [965]. Mutations that lower IGF1 levels in mice retard growth and extend lifespan [287], even if a definitive causative relation between IGF1 and ageing has not been demonstrated. In another study, including three different mice cohorts, it was reported that IGF1-deficient mutants, producing reduced levels of IGF-1, display an increase in maximum lifespan, but not in the mean lifespan [3528]. Contrastly, congenital liver IGF-1-deficient male mice, have a reduced lifespan (by ~20%). Additionally, inducibly deleting the liver Igf-1 gene at one year of age, impairs health span; mice display compromised skeletal integrity, decreased body, kidney and quadriceps weight, and an increase in liver weight, inflammation, oxidative stress and tumors [3556]. Genotype combinations in the human PIK3CB and IGF1R genes have been related to plasma IGF1 levels and longevity [141]. Cardiac specific overexpression of IGF1 results in a 23% increase in median lifespan, though no increase in maximum lifespan [1902]. In humans, IGF1 levels have been associated with several pathologies. High levels of IGF1 have been found to be associated with risk of breast cancer [993]. On the other hand, low levels of IGF1 have been associated with osteoporosis [1923]. Low levels of IGF-1 in nonagenarians females (but not males), and both males and females with a history of cancer, predicts longer survival chances [3599]. Despite being a putative regulator of ageing, IGF1's exact influence on human ageing is not known.

Cytogenetic information

Cytogenetic band
12q23.2
Location
102,395,867 bp to 102,480,645 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001501; skeletal system development
GO:0001974; blood vessel remodeling
GO:0002576; platelet degranulation
GO:0006260; DNA replication
GO:0006928; cellular component movement
GO:0007165; signal transduction
GO:0007265; Ras protein signal transduction
GO:0007517; muscle organ development
GO:0007596; blood coagulation
GO:0008284; positive regulation of cell proliferation
GO:0008285; negative regulation of cell proliferation
And 62 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005886; plasma membrane
GO:0016942; insulin-like growth factor binding protein complex
GO:0031093; platelet alpha granule lumen
Function: GO:0005158; insulin receptor binding
GO:0005159; insulin-like growth factor receptor binding
GO:0005178; integrin binding
GO:0005179; hormone activity
GO:0005515; protein binding
GO:0008083; growth factor activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
IGF1R, IGFBP3
STRING interaction network
Protein-Protein network diagram for IGF1

Retrieve sequences for IGF1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
igf1
Mus musculus
Igf1
Rattus norvegicus
Igf1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Igf1
LongevityMap
  • This gene is present as IGF1

Selected references

External links

EPD
ORF Accession
NM_000618
CDS Accession
NP_000609
OMIM
147440
HPRD
00936
Ensembl
IGF1
UniProt/Swiss-Prot
IGF1B_HUMAN
GeneCards
IGF1
Entrez Gene
3479
UniGene
160562
GenAtlas
IGF1
Internet
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