GenAge entry for HSPA1A (Homo sapiens)

Gene name (HAGRID: 160)

HGNC symbol
HSPA1A 
Aliases
HSP72; HSPA1; HSP70I; HSP70-1; HSP70-1A 
Common name
heat shock 70kDa protein 1A 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

The HSPA1A protein, also known as hsp72 or hsp70, is a stress-induced chaperone [757]. Results from invertebrates have suggested that heat-shock proteins, such as HSPA1A, are involved in ageing. Overexpression of hsp70, a homologue of HSPA1A, extends lifespan in fruit flies [210]. Induction of HSPA1A after ischemia is diminished in aged rat hearts [908]. Overexpression of HSPA1A in mice with spinocerebellar ataxia type 1 offered protection against this disease, suggesting HSPA1A could protect against neurodegeneration [755]. However, in a more recent study, overexpression of hsp70 in mice was associated with growth retardation, tumor formation, and early death [1978]. Whether HSPA1A is related to human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
6p21.3
Location
31,891,315 bp to 31,893,698 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser

Protein information

Gene Ontology
Process:
Cellular component:
Function:
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, PEX5, BCL2, HSP90AA1, NR3C1, HSF1, AIFM1, MAP3K5, APEX1, STUB1
STRING interaction network
Protein-Protein network diagram for HSPA1A

Retrieve sequences for HSPA1A

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

No homologs found

In other databases

LongevityMap
  • This gene is present as HSPA1A

Selected references

External links

EPD
HS_HSPA1A
ORF Accession
NM_005345
CDS Accession
NP_005336
OMIM
140550
HPRD
00774
Ensembl
HSPA1A
UniProt/Swiss-Prot
HSP71_HUMAN
GeneCards
HSPA1A
Entrez Gene
3303
UniGene
520028
GenAtlas
HSPA1A
Internet
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