GenAge entry for HSPA1A (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 160)

HGNC symbol
HSPA1A 
Aliases
HSP70-1; HSPA1 
Common name
heat shock 70kDa protein 1A 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

The HSPA1A protein, also known as hsp72 or hsp70, is a stress-induced chaperone [757]. Results from invertebrates have suggested that heat-shock proteins, such as HSPA1A, are involved in ageing. Overexpression of hsp70, a homologue of HSPA1A, extends lifespan in fruit flies [210]. Induction of HSPA1A after ischemia is diminished in aged rat hearts [908]. Overexpression of HSPA1A in mice with spinocerebellar ataxia type 1 offered protection against this disease, suggesting HSPA1A could protect against neurodegeneration [755]. However, in a more recent study, overexpression of hsp70 in mice was associated with growth retardation, tumor formation, and early death [1978]. Hsp70 basal levels show tissue-specific age-associated variations and are preserved in long-lived mice. Hsp70 levels from long-lived mice are similar to those found in adult WT mice. In adult PAM mice, which normally show accelerated aging, hsp70 levels are similar to those in chronologically old animals [4364]. Whether HSPA1A is related to human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
6p21.3
Location
31,815,514 bp to 31,817,942 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0010628; positive regulation of gene expression
GO:0010941; regulation of cell death
GO:0030512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031396; regulation of protein ubiquitination
GO:0031397; negative regulation of protein ubiquitination
GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032757; positive regulation of interleukin-8 production
GO:0034599; cellular response to oxidative stress
GO:0034605; cellular response to heat
GO:0042026; protein refolding
GO:0043488; regulation of mRNA stability
And 17 more GO terms
Cellular component: GO:0000151; ubiquitin ligase complex
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005814; centriole
GO:0005829; cytosol
GO:0005913; cell-cell adherens junction
GO:0005925; focal adhesion
GO:0016234; inclusion body
GO:0048471; perinuclear region of cytoplasm
GO:0072562; blood microparticle
And 1 more GO terms
Function: GO:0001618; virus receptor activity
GO:0001664; G-protein coupled receptor binding
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016887; ATPase activity
GO:0019899; enzyme binding
GO:0031072; heat shock protein binding
GO:0031625; ubiquitin protein ligase binding
GO:0042623; ATPase activity, coupled
GO:0042826; histone deacetylase binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, TERT, MYC, EGFR, FOS, PTEN, BCL2, VCP, HSP90AA1, NR3C1, STK11, AR, EMD, HSF1, AIFM1, RELA, HSPD1, MAP3K5, BMI1, EEF1A1, HSPA8, MAPT, MAX, H2AFX, STUB1, CDKN1A, SPRTN
STRING interaction network
Protein-Protein network diagram for HSPA1A

Retrieve sequences for HSPA1A

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

No homologs found

In other databases

LongevityMap
  • This gene is present as HSPA1A

Selected references

External links

EPD
HS_HSPA1A
ORF Accession
NM_005345
CDS Accession
NP_005336
OMIM
140550
HPRD
00774
Ensembl
HSPA1A
UniProt/Swiss-Prot
HSP71_HUMAN
GeneCards
HSPA1A
Entrez Gene
3303
UniGene
520028
GenAtlas
HSPA1A
Internet
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