GenAge entry for HOXB7 (Homo sapiens)

Gene name (HAGRID: 213)

HGNC symbol
HOXB7 
Aliases
HOX2; HOX2C 
Common name
homeobox B7 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

HOXB7 is a member of the homeobox family, also called HOX, crucial in morphogenesis and development [1024]. The expression of many HOX genes, including HOXB7, declines with age, even prior to adulthood [1020]. An association of HOX genes with longevity has been proposed [1022], though there is no direct evidence linking HOXB7 to human ageing.

Cytogenetic information

Cytogenetic band
17q21.3
Location
48,607,233 bp to 48,611,021 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-dependent
GO:0007275; multicellular organismal development
GO:0009952; anterior/posterior pattern specification
GO:0030099; myeloid cell differentiation
GO:0048704; embryonic skeletal system morphogenesis
GO:0090190; positive regulation of branching involved in ureteric bud morphogenesis
Cellular component: GO:0005634; nucleus
GO:0005730; nucleolus
GO:0005737; cytoplasm
Function: GO:0003700; sequence-specific DNA binding transcription factor activity
GO:0005515; protein binding
GO:0043565; sequence-specific DNA binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
CREBBP, NFKBIA
STRING interaction network
Protein-Protein network diagram for HOXB7

Retrieve sequences for HOXB7

ORF
ORF
CDS
CDS

Homologs in model organisms

Drosophila melanogaster
lbe
Danio rerio
hoxb7a
Mus musculus
Hoxb7
Rattus norvegicus
Hoxb7

Selected references

External links

EPD
ORF Accession
NM_004502
CDS Accession
NP_004493
OMIM
142962
HPRD
00850
Ensembl
HOXB7
UniProt/Swiss-Prot
HXB7_HUMAN
GeneCards
HOXB7
Entrez Gene
3217
UniGene
436181
GenAtlas
HOXB7
Internet
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