GenAge entry for TOP1 (Homo sapiens)

Gene name (HAGRID: 83)

HGNC symbol
TOP1 
Aliases
 
Common name
topoisomerase (DNA) I 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Topoisomerases regulate the topological states of DNA. Though no direct interaction has been reported, TOP1 has been indirectly linked to WRN [487]. TOP1 may also be important in the regulation of various brain functions and its activity is age-dependent [1625]. Because TOP1 has been associated with several DNA metabolism proteins thought to play a role in ageing, it is possible that TOP1 is itself involved in human ageing, though further studies are necessary to confirm this hypothesis.

Cytogenetic information

Cytogenetic band
20q12-q13.
Location
41,028,822 bp to 41,124,486 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006260; DNA replication
GO:0006265; DNA topological change
GO:0006338; chromatin remodeling
GO:0007059; chromosome segregation
GO:0012501; programmed cell death
GO:0016310; phosphorylation
GO:0019048; modulation by virus of host morphology or physiology
GO:0040016; embryonic cleavage
GO:0042493; response to drug
Cellular component: GO:0000228; nuclear chromosome
GO:0000932; cytoplasmic mRNA processing body
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0031298; replication fork protection complex
GO:0043204; perikaryon
Function: GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003917; DNA topoisomerase type I activity
GO:0003918; DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005515; protein binding
GO:0005524; ATP binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, WRN, UBE2I, PCNA, SUMO1
STRING interaction network
Protein-Protein network diagram for TOP1

Retrieve sequences for TOP1

ORF
ORF
CDS
CDS

Homologs in model organisms

Drosophila melanogaster
Top1
Danio rerio
top1l
Mus musculus
Top1
Rattus norvegicus
Top1

In other databases

CellAge
  • This gene is present as TOP1

Selected references

External links

EPD
ORF Accession
NM_003286
CDS Accession
NP_003277
OMIM
126420
HPRD
00535
Ensembl
TOP1
UniProt/Swiss-Prot
TOP1_HUMAN
GeneCards
TOP1
Entrez Gene
7150
UniGene
472737
GenAtlas
TOP1
Internet
Search Google