GenAge entry for TPP2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 273)

HGNC symbol
TPP2 
Aliases
 
Common name
tripeptidyl peptidase II 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

In human embryonic kidney cells overexpression of TPP2 induces accelerated growth and resistance to apoptosis, correlated with the appearance of multiple chromosomal aberrations, numerical and structural centrosome abnormalities, and multipolar cell divisions, suggesting a role in the regulation of centrosome homeostasis and mitotic fidelity [2185].

Knockout in mice resulted in viable animals which are almost indistinguishable from their wild type littermates when young. After the age of 1 year mutant mice show an increased mortality and multiple signs of premature ageing. They exhibt an aged appearance, disheveled fur, large bald areas, reduced body mass, and loss of vigor. Mice also show symptoms characteristic of immunohematopoietic senescence, including accelerated thymic involution, lymphopenia, impaired proliferative T cell responses, extramedullary hematopoiesis, and inflammation. Premature cellular senescence in fibroblasts, coinciding with the upregulation of TP53 and the dysregulation of NFKB1 was also observed [2184].

Cytogenetic information

Cytogenetic band
13q32-q33
Location
102,596,936 bp to 102,679,173 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000209; protein polyubiquitination
GO:0006508; proteolysis
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0004175; endopeptidase activity
GO:0004177; aminopeptidase activity
GO:0004252; serine-type endopeptidase activity
GO:0005515; protein binding
GO:0008240; tripeptidyl-peptidase activity
GO:0042277; peptide binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
POLB, SIRT7
STRING interaction network
Protein-Protein network diagram for TPP2

Retrieve sequences for TPP2

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
F21H12.6
Danio rerio
tpp2
Drosophila melanogaster
TppII
Mus musculus
Tpp2
Rattus norvegicus
Tpp2
Schizosaccharomyces pombe
tpp2

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Tpp2

Selected references

External links

EPD
ORF Accession
NM_003291
CDS Accession
NP_003282
OMIM
190470
HPRD
01834
Ensembl
TPP2
UniProt/Swiss-Prot
Q5VZU9_HUMAN
GeneCards
TPP2
Entrez Gene
7174
UniGene
432424
GenAtlas
TPP2
Internet
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