GenAge entry for HOXC4 (Homo sapiens)

Gene name (HAGRID: 214)

HGNC symbol
HOXC4 
Aliases
HOX3; HOX3E 
Common name
homeobox C4 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

HOXC4 is a member of the homeobox family, also called HOX, crucial in morphogenesis and development [1024]. The expression of many HOX genes, including HOXC4, declines with age, even prior to adulthood [1020]. HOXC4 also interacts with XRCC6 and PRKDC [1017]. An association of HOX genes with longevity has been proposed [1022], though there is no direct evidence linking HOXC4 to human ageing.

Cytogenetic information

Cytogenetic band
12q13.3
Location
54,053,877 bp to 54,056,030 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-dependent
GO:0007275; multicellular organismal development
GO:0009952; anterior/posterior pattern specification
GO:0048562; embryonic organ morphogenesis
GO:0051216; cartilage development
Cellular component: GO:0005634; nucleus
Function: GO:0003700; sequence-specific DNA binding transcription factor activity
GO:0005515; protein binding
GO:0043565; sequence-specific DNA binding
GO:0071837; HMG box domain binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
PRKDC, XRCC6
STRING interaction network
Protein-Protein network diagram for HOXC4

Retrieve sequences for HOXC4

ORF
ORF
CDS
CDS

Homologs in model organisms

Drosophila melanogaster
Scr
Danio rerio
hoxc4a
Mus musculus
Hoxc4

Selected references

External links

EPD
ORF Accession
NM_153633
CDS Accession
NP_705897
OMIM
142974
HPRD
00860
Ensembl
HOXC4
UniProt/Swiss-Prot
HXC4_HUMAN
GeneCards
HOXC4
Entrez Gene
3221
UniGene
549040
GenAtlas
HOXC4
Internet
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