GenAge entry for FOXO4 (Homo sapiens)

Gene name (HAGRID: 183)

HGNC symbol
FOXO4 
Aliases
AFX1; MLLT7 
Common name
forkhead box O4 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

A member of the forkhead family, FOXO4 plays a role in development [802] and in insulin (INS) signalling. In roundworms, a homologue of FOXO4, daf-16, has been associated with ageing [628], and overexpression of another homologue, dFOXO, in adult fat body of fruit flies increased longevity in females [1238]. FOXO4's role in human ageing has not been determined.

Cytogenetic information

Cytogenetic band
Xq13.1
Location
71,096,149 bp to 71,103,534 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0007050; cell cycle arrest
GO:0007095; mitotic G2 DNA damage checkpoint
GO:0007517; muscle organ development
GO:0007568; aging
GO:0008285; negative regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
GO:0014911; positive regulation of smooth muscle cell migration
GO:0016525; negative regulation of angiogenesis
GO:0031667; response to nutrient levels
And 7 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008013; beta-catenin binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0042802; identical protein binding
GO:0043565; sequence-specific DNA binding
GO:1990841; promoter-specific chromatin binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
AKT1, PIN1, CREBBP, FEN1, FOXO1, SIRT1, MDM2, ESR1, CTNNB1
STRING interaction network
Protein-Protein network diagram for FOXO4

Retrieve sequences for FOXO4

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
LOC563719
Drosophila melanogaster
foxo
Mus musculus
Foxo4
Rattus norvegicus
Foxo4
Saccharomyces cerevisiae
FHL1
Schizosaccharomyces pombe
sep1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as foxo
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as foxo
LongevityMap
  • This gene is present as FOXO4

Selected references

External links

EPD
ORF Accession
NM_005938
CDS Accession
NP_005929
OMIM
300033
HPRD
02070
Ensembl
FOXO4
UniProt/Swiss-Prot
FOXO4_HUMAN
GeneCards
FOXO4
Entrez Gene
4303
UniGene
584654
GenAtlas
FOXO4
Internet
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