GenAge entry for TERC (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 7)

HGNC symbol
TERC 
Aliases
TR; hTR; TRC3; DKCA1; PFBMFT2; SCARNA19 
Common name
telomerase RNA component 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

The RNA component of telomerase, TERC is involved in elongating the telomeres and is a critical factor in cellular senescence [21].

TERC disruption in mice shortens lifespan and increases tumour incidence but it does not appear to accelerate ageing [29]. Late-generation mice with disrupted TERC, and hence with shorter telomeres, when combined with mutations in ATM [12] or WRN [1069] may suffer from accelerated ageing. Telomere shortening in mice lacking TERC also appears to impact on the pathologies caused by mutations in BLM [1149]. Human mutations in TERC are a cause of dyskeratosis congenita, a skin and bone marrow failure syndrome which is not classified as accelerated ageing [114].

Cytogenetic information

Cytogenetic band
3q26
Location
127,471,195 bp to 127,495,720 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser

Protein information

Gene Ontology
Process:
Cellular component:
Function:
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TERT, PRKDC
STRING interaction network
Protein-Protein network diagram for TERC

Retrieve sequences for TERC

ORF
ORF

Homologs in model organisms

No homologs found

In other databases

LongevityMap
  • This gene is present as TERC

Selected references

External links

EPD
ORF Accession
NR_001566
CDS Accession
OMIM
602322
HPRD
Ensembl
TERC
UniProt/Swiss-Prot
GeneCards
TERC
Entrez Gene
7012
UniGene
436182
GenAtlas
TERC
Internet
Search Google