GenAge entry for INS (Homo sapiens)

Gene name (HAGRID: 30)

HGNC symbol
INS 
Aliases
IDDM2; IDDM1 
Common name
insulin 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Insulin is produced by cells in the islets of Langerhans in the pancreas. It decreases blood glucose concentration and regulates the cellular metabolism of monosaccharides, amino acids and fatty acids.

As with IGF1, INS may be involved in the ageing process of model organisms [284]. In roundworms, expression of the human insulin gene enhances dauer formation and slightly increases lifespan [960]. Despite the well-established age-related onset of type 2 diabetes, and possible roles of INS in other age-related diseases [312], the impact of INS on human ageing is unclear.

Cytogenetic information

Cytogenetic band
11p15.5
Location
2,159,778 bp to 2,161,209 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0002674; negative regulation of acute inflammatory response
GO:0006006; glucose metabolic process
GO:0006112; energy reserve metabolic process
GO:0006355; regulation of transcription, DNA-dependent
GO:0006521; regulation of cellular amino acid metabolic process
GO:0006953; acute-phase response
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0008284; positive regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
And 51 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005788; endoplasmic reticulum lumen
GO:0005796; Golgi lumen
GO:0031904; endosome lumen
GO:0034774; secretory granule lumen
Function: GO:0002020; protease binding
GO:0005158; insulin receptor binding
GO:0005159; insulin-like growth factor receptor binding
GO:0005179; hormone activity
GO:0005515; protein binding
GO:0042802; identical protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
IGF1R, IRS2, INSR, LRP2, LEP
STRING interaction network
Protein-Protein network diagram for INS

Retrieve sequences for INS

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ins
Mus musculus
Ins1
Rattus norvegicus
Ins1

In other databases

LongevityMap
  • This gene is present as INS

Selected references

External links

EPD
HS_INS
ORF Accession
NM_000207
CDS Accession
NP_000198
OMIM
176730
HPRD
01455
Ensembl
INS
UniProt/Swiss-Prot
INS_HUMAN
GeneCards
INS
Entrez Gene
3630
UniGene
654579
GenAtlas
INS
Internet
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