GenAge entry for PTGS2 (Homo sapiens)

Gene name (HAGRID: 198)

HGNC symbol
PTGS2 
Aliases
COX2 
Common name
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

PTGS2 may play a role in inflammation. PTGS2-null mice developed severe nephropathy [864] and female reproductive failures [1734]. Age-related changes in PTGS2 have been reported in various tissues in mice [863]. PTGS2 has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band
1q25.2-q25
Location
186,671,812 bp to 186,680,427 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001516; prostaglandin biosynthetic process
GO:0001525; angiogenesis
GO:0006693; prostaglandin metabolic process
GO:0006769; nicotinamide metabolic process
GO:0006928; movement of cell or subcellular component
GO:0006954; inflammatory response
GO:0006979; response to oxidative stress
GO:0007566; embryo implantation
GO:0007612; learning
GO:0007613; memory
GO:0008217; regulation of blood pressure
And 49 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005783; endoplasmic reticulum
GO:0005788; endoplasmic reticulum lumen
GO:0005789; endoplasmic reticulum membrane
GO:0005901; caveola
GO:0031090; organelle membrane
GO:0043005; neuron projection
GO:0043234; protein complex
Function: GO:0004601; peroxidase activity
GO:0004666; prostaglandin-endoperoxide synthase activity
GO:0005515; protein binding
GO:0008289; lipid binding
GO:0019899; enzyme binding
GO:0020037; heme binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding
GO:0050473; arachidonate 15-lipoxygenase activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, VCP, EP300, APP, MAPK3, PTGS2, SUMO1, CTNNB1
STRING interaction network
Protein-Protein network diagram for PTGS2

Retrieve sequences for PTGS2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ptgs2b
Mus musculus
Ptgs2
Rattus norvegicus
Ptgs2

Selected references

External links

EPD
ORF Accession
NM_000963
CDS Accession
NP_000954
OMIM
600262
HPRD
02599
Ensembl
PTGS2
UniProt/Swiss-Prot
PGH2_HUMAN
GeneCards
PTGS2
Entrez Gene
5743
UniGene
196384
GenAtlas
PTGS2
Internet
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