GenAge entry for LMNB1 (Homo sapiens)

Gene name (HAGRID: 181)

HGNC symbol
LMNB1 
Aliases
 
Common name
lamin B1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

LMNAB1 is, like LMNA, part of the nuclear lamina [1001]. LMNB1-null mice die shortly after birth [1724]. If the nuclear lamina is a player in human ageing, as some results from LMNA suggest [1307], then it is possible that LMNB1 also plays some role in human ageing.

Cytogenetic information

Cytogenetic band
5q23.2
Location
126,776,623 bp to 126,837,020 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process:
Cellular component: GO:0005635; nuclear envelope
GO:0005637; nuclear inner membrane
GO:0005638; lamin filament
GO:0005654; nucleoplasm
GO:0016020; membrane
GO:0016363; nuclear matrix
GO:0031965; nuclear membrane
Function: GO:0005198; structural molecule activity
GO:0005515; protein binding
GO:0043274; phospholipase binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
LMNA, EGF, RPA1, PRKCA, EMD, HSPA8, CDK1, CTNNB1, SPRTN
STRING interaction network
Protein-Protein network diagram for LMNB1

Retrieve sequences for LMNB1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
lmnb1
Mus musculus
Lmnb1
Rattus norvegicus
Lmnb1

Selected references

External links

EPD
ORF Accession
NM_005573
CDS Accession
NP_005564
OMIM
150340
HPRD
01036
Ensembl
LMNB1
UniProt/Swiss-Prot
LMNB1_HUMAN
GeneCards
LMNB1
Entrez Gene
4001
UniGene
89497
GenAtlas
LMNB1
Internet
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