GenAge entry for HDAC3 (Homo sapiens)

Gene name (HAGRID: 25)

HGNC symbol
HDAC3 
Aliases
RPD3; HD3; RPD3-2 
Common name
histone deacetylase 3 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

HDAC3 performs the deacetylation of histones and likely participates in transcriptional regulation [736]. Homologues of HDAC3 have been linked to longevity in yeast [203] and to ageing and caloric restriction in fruit flies [202]. Its relation to human ageing is not known, yet because of its many functions, it is possible that HDAC3 plays some role on ageing.

Cytogenetic information

Cytogenetic band
5q31
Location
141,620,876 bp to 141,636,856 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001934; positive regulation of protein phosphorylation
GO:0006325; chromatin organization
GO:0006351; transcription, DNA-templated
GO:0006476; protein deacetylation
GO:0007623; circadian rhythm
GO:0010832; negative regulation of myotube differentiation
GO:0031647; regulation of protein stability
GO:0032008; positive regulation of TOR signaling
GO:0042993; positive regulation of transcription factor import into nucleus
GO:0043066; negative regulation of apoptotic process
And 8 more GO terms
Cellular component: GO:0000118; histone deacetylase complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0005876; spindle microtubule
GO:0005886; plasma membrane
GO:0017053; transcriptional repressor complex
Function: GO:0003682; chromatin binding
GO:0003714; transcription corepressor activity
GO:0004407; histone deacetylase activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0030332; cyclin binding
GO:0032041; NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558; protein deacetylase activity
GO:0042826; histone deacetylase binding
GO:0051059; NF-kappaB binding
And 1 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
STAT3, HDAC3, AKT1, MYC, NCOR1, PARP1, PIN1, CREBBP, HIF1A, TOP2B, NFKB1, EP300, PML, PRKDC, AR, RB1, EMD, RELA, MAPK14, SP1, JUN, PIK3R1, APEX1, HSPA8, ESR1, NFKBIA, PPP1CA, PPARG, NCOR2, NFE2L2
STRING interaction network
Protein-Protein network diagram for HDAC3

Retrieve sequences for HDAC3

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
hdac3
Drosophila melanogaster
Hdac3
Mus musculus
Hdac3
Rattus norvegicus
Hdac3

Selected references

External links

EPD
ORF Accession
NM_003883
CDS Accession
NP_003874
OMIM
605166
HPRD
08950
Ensembl
HDAC3
UniProt/Swiss-Prot
HDAC3_HUMAN
GeneCards
HDAC3
Entrez Gene
8841
UniGene
519632
GenAtlas
HDAC3
Internet
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