GenAge entry for PTK2 (Homo sapiens)

Gene name (HAGRID: 166)

HGNC symbol
PTK2 
Aliases
FAK; FADK; FAK1; PPP1R71 
Common name
protein tyrosine kinase 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

PTK2, also known as focal adhesion kinase (FAK), plays a role in the signal transduction of a number of pathways such as MAPK signalling, apoptosis, cellular proliferation, and cellular senescence [998]. PTK2 deletion in the epidermis of mice suppresses tumour formation [1717]. Its role, if any, in human ageing is unknown, but PTK2 could potentially be involved in downstream signalling cascades related to ageing.

Cytogenetic information

Cytogenetic band
8q24.3
Location
140,658,382 bp to 141,001,313 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0000226; microtubule cytoskeleton organization
GO:0001525; angiogenesis
GO:0001570; vasculogenesis
GO:0001764; neuron migration
GO:0001890; placenta development
GO:0001932; regulation of protein phosphorylation
GO:0001934; positive regulation of protein phosphorylation
GO:0003007; heart morphogenesis
GO:0006921; cellular component disassembly involved in execution phase of apoptosis
GO:0007172; signal complex assembly
And 45 more GO terms
Cellular component: GO:0001725; stress fiber
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005815; microtubule organizing center
GO:0005829; cytosol
GO:0005856; cytoskeleton
GO:0005886; plasma membrane
GO:0005925; focal adhesion
GO:0005938; cell cortex
GO:0016324; apical plasma membrane
GO:0030027; lamellipodium
And 2 more GO terms
Function: GO:0003779; actin binding
GO:0004672; protein kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0004871; signal transducer activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008432; JUN kinase binding
GO:0019901; protein kinase binding
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, IGF1R, PTPN11, STAT3, IRS1, EGFR, ERBB2, RET, PARP1, PTEN, HSP90AA1, GSK3B, GRB2, APP, PTK2, PIK3R1, MDM2, JAK2, PPP1CA, STUB1, SOCS2
STRING interaction network
Protein-Protein network diagram for PTK2

Retrieve sequences for PTK2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ptk2.1
Mus musculus
Ptk2
Rattus norvegicus
Ptk2

Selected references

External links

EPD
ORF Accession
NM_153831
CDS Accession
NP_722560
OMIM
600758
HPRD
02859
Ensembl
PTK2
UniProt/Swiss-Prot
FAK1_HUMAN
GeneCards
PTK2
Entrez Gene
5747
UniGene
395482
GenAtlas
PTK2
Internet
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