GenAge entry for TERT (Homo sapiens)

Gene name (HAGRID: 8)

HGNC symbol
TERT 
Aliases
TRT; TP2; TCS1; hEST2; EST2 
Common name
telomerase reverse transcriptase 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

Telomerase repairs/elongates the telomeres and is crucial in cellular proliferation. TERT expression is sufficient to overcome cellular senescence in culture [24], but overexpression of TERT in mice does not extend longevity [30]. Most human cell lines have low or insignificant levels of TERT while cancer cells often have high levels [102]. Cardiac-specific Tert activation after myocardial infarction in adult mice results in attenuated cardiac dilation, improved ventricular function, smaller infarct scars and increased mouse survival [3624]. In humans, mutations in TERT have been linked to aplastic anaemia [1465]. As such, TERT appears to be an important player in cellular proliferation, even if its relation to human ageing remains obscure.

Cytogenetic information

Cytogenetic band
5p15.33
Location
1,253,147 bp to 1,295,069 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000723; telomere maintenance
GO:0001172; transcription, RNA-templated
GO:0006278; RNA-dependent DNA biosynthetic process
GO:0007004; telomere maintenance via telomerase
GO:0007005; mitochondrion organization
GO:0010629; negative regulation of gene expression
GO:0022616; DNA strand elongation
GO:0030177; positive regulation of Wnt signaling pathway
GO:0030422; production of siRNA involved in RNA interference
GO:0031647; regulation of protein stability
GO:0032092; positive regulation of protein binding
And 25 more GO terms
Cellular component: GO:0000333; telomerase catalytic core complex
GO:0000781; chromosome, telomeric region
GO:0000783; nuclear telomere cap complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005697; telomerase holoenzyme complex
GO:0005730; nucleolus
GO:0005886; plasma membrane
GO:0016605; PML body
GO:0031379; RNA-directed RNA polymerase complex
And 3 more GO terms
Function: GO:0000049; tRNA binding
GO:0001223; transcription coactivator binding
GO:0003677; DNA binding
GO:0003720; telomerase activity
GO:0003721; telomerase RNA reverse transcriptase activity
GO:0003723; RNA binding
GO:0003964; RNA-directed DNA polymerase activity
GO:0003968; RNA-directed 5'-3' RNA polymerase activity
GO:0005515; protein binding
GO:0016779; nucleotidyltransferase activity
GO:0042162; telomeric DNA binding
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, TERC, AKT1, HSP90AA1, PML, TERF1, XRCC5, XRCC6, FOXO3, RELA, HSPA1A, YWHAZ, MDM2, MTOR, ATR, STUB1
STRING interaction network
Protein-Protein network diagram for TERT

Retrieve sequences for TERT

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
tert
Mus musculus
Tert
Rattus norvegicus
Tert
Saccharomyces cerevisiae
EST2
Schizosaccharomyces pombe
trt1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Tert
LongevityMap
  • This gene is present as TERT
CellAge
  • This gene is present as TERT

Selected references

External links

EPD
ORF Accession
NM_003219
CDS Accession
NP_003210
OMIM
187270
HPRD
01754
Ensembl
TERT
UniProt/Swiss-Prot
TERT_HUMAN
GeneCards
TERT
Entrez Gene
7015
UniGene
492203
GenAtlas
TERT
Internet
Search Google