GenAge entry for ABL1 (Homo sapiens)

Gene name (HAGRID: 78)

HGNC symbol
ABL1 
Aliases
JTK7; c-ABL; p150; ABL 
Common name
ABL proto-oncogene 1, non-receptor tyrosine kinase 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

An important player in cellular proliferation and development, ABL1 also acts as an oncogene [471]. Some results indicate ABL1 might also be involved in DNA repair [474]. Disruption of ABL1 in mice results in severe defects and animals die shortly after birth [472]. Although its exact functions remain elusive, ABL1 has been argued to play a role in ageing due to its interaction with ageing-related genes, such as ATM, and its functions [1292].

Cytogenetic information

Cytogenetic band
9q34.1
Location
130,713,881 bp to 130,887,675 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006298; mismatch repair
GO:0006355; regulation of transcription, DNA-dependent
GO:0006464; cellular protein modification process
GO:0006914; autophagy
GO:0006974; cellular response to DNA damage stimulus
GO:0006975; DNA damage induced protein phosphorylation
GO:0007155; cell adhesion
GO:0007411; axon guidance
GO:0007596; blood coagulation
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010506; regulation of autophagy
And 19 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0015629; actin cytoskeleton
GO:0031252; cell leading edge
GO:0031965; nuclear membrane
GO:0048471; perinuclear region of cytoplasm
Function: GO:0000287; magnesium ion binding
GO:0003677; DNA binding
GO:0003785; actin monomer binding
GO:0004515; nicotinate-nucleotide adenylyltransferase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0017124; SH3 domain binding
GO:0019905; syntaxin binding
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ATM, PRKDC, XRCC6, RB1, GRB2, GPX1
STRING interaction network
Protein-Protein network diagram for ABL1

Retrieve sequences for ABL1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
abl-1
Drosophila melanogaster
Abl
Danio rerio
abl1
Mus musculus
Abl1
Rattus norvegicus
Abl1

Selected references

External links

EPD
HS_ABL1_3
ORF Accession
NM_007313
CDS Accession
NP_009297
OMIM
189980
HPRD
01809
Ensembl
ABL1
UniProt/Swiss-Prot
ABL1_HUMAN
GeneCards
ABL1
Entrez Gene
25
UniGene
431048
GenAtlas
ABL1
Internet
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