GenAge entry for PIK3CB (Homo sapiens)

Gene name (HAGRID: 36)

HGNC symbol
PIK3CB 
Aliases
PIK3C1 
Common name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

PIK3CB is involved in the signal transduction of insulin (INS) and insulin-like pathways including the activation of the MAPK pathway [154]. A homologue of PIK3CB, age-1, has been related to ageing in roundworms [1518]. Genotype combinations in the human PIK3CB and IGF1R genes have been related to plasma IGF1 levels and longevity [141], though the elucidation of PIK3CB's role in ageing will require more detailed studies.

Cytogenetic information

Cytogenetic band
3q22.3
Location
138,652,698 bp to 138,759,359 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000187; activation of MAPK activity
GO:0001952; regulation of cell-matrix adhesion
GO:0006644; phospholipid metabolic process
GO:0006661; phosphatidylinositol biosynthetic process
GO:0006874; cellular calcium ion homeostasis
GO:0006914; autophagy
GO:0006935; chemotaxis
GO:0007156; homophilic cell adhesion
GO:0007165; signal transduction
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173; epidermal growth factor receptor signaling pathway
And 20 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005942; phosphatidylinositol 3-kinase complex
Function: GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0035004; phosphatidylinositol 3-kinase activity
GO:0035005; 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560; insulin receptor substrate binding
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
AKT1, PIK3R1
STRING interaction network
Protein-Protein network diagram for PIK3CB

Retrieve sequences for PIK3CB

ORF
ORF
CDS
CDS

Homologs in model organisms

Drosophila melanogaster
Pi3K92E
Danio rerio
pik3cb
Mus musculus
Pik3cb
Rattus norvegicus
Pik3cb

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Pi3K92E
LongevityMap
  • This gene is present as PIK3CB

Selected references

External links

EPD
ORF Accession
NM_006219
CDS Accession
NP_006210
OMIM
602925
HPRD
04234
Ensembl
PIK3CB
UniProt/Swiss-Prot
PK3CB_HUMAN
GeneCards
PIK3CB
Entrez Gene
5291
UniGene
239818
GenAtlas
PIK3CB
Internet
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