GenAge entry for FOXM1 (Homo sapiens)

Gene name (HAGRID: 131)

HGNC symbol
FOXM1 
Aliases
HFH-11; trident; HNF-3; INS-1; MPP2; MPHOSPH2; TGT3; FKHL16 
Common name
forkhead box M1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

A transcriptional regulator that is important in development, FOXM1 may also play a role in cell proliferation. In invertebrates, such as roundworms, the forkhead family has been linked to ageing [957]. In mice, FOXM1 has been associated with GH1-stimulated liver regeneration. Increased expression of FOXM1 in old mice restored hepatocyte proliferation to levels found in young animals [276]. It remains to be determined whether FOXM1 is involved in human ageing.

Cytogenetic information

Cytogenetic band
12p13
Location
2,857,681 bp to 2,877,155 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000086; G2/M transition of mitotic cell cycle
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006281; DNA repair
GO:0006351; transcription, DNA-templated
GO:0006978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008284; positive regulation of cell proliferation
GO:0032873; negative regulation of stress-activated MAPK cascade
GO:0045892; negative regulation of transcription, DNA-templated
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0046578; regulation of Ras protein signal transduction
And 6 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
Function: GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0019901; protein kinase binding
GO:0043565; sequence-specific DNA binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
CREBBP, HSP90AA1, UBE2I, GSK3B, TERF1, RB1, SP1, CDK1, SUMO1, CTNNB1, CHEK2, GSK3A
STRING interaction network
Protein-Protein network diagram for FOXM1

Retrieve sequences for FOXM1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
foxm1
Mus musculus
Foxm1
Rattus norvegicus
Foxm1

In other databases

CellAge
  • This gene is present as FOXM1

Selected references

External links

EPD
ORF Accession
NM_021953
CDS Accession
NP_068772
OMIM
602341
HPRD
03823
Ensembl
FOXM1
UniProt/Swiss-Prot
FOXM1_HUMAN
GeneCards
FOXM1
Entrez Gene
2305
UniGene
239
GenAtlas
FOXM1
Internet
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