GenAge entry for PROP1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 5)

HGNC symbol
PROP1 
Aliases
 
Common name
PROP paired-like homeobox 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

A transcription factor involved in hormonal regulation and development, PROP1 sits upstream of POU1F1 [355]. The Ames dwarf, a mouse strain mutant for PROP1, is remarkably long-lived with some evidence of delayed ageing [10]. On the other hand, PROP1 mutations in mice are strongly influenced by genetic background and can be lethal in some cases [1802]. Human mutations in PROP1 result in pituitary hormone deficiency, typically characterized by growth retardation. Although some individuals may be long-lived 0142, it is not known to what extent and in what direction PROP1 mutations affect the human ageing process [1345].

Cytogenetic information

Cytogenetic band
5q35.3
Location
177,992,235 bp to 177,996,242 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001568; blood vessel development
GO:0006366; transcription from RNA polymerase II promoter
GO:0007417; central nervous system development
GO:0009953; dorsal/ventral pattern formation
GO:0016477; cell migration
GO:0021979; hypothalamus cell differentiation
GO:0043066; negative regulation of apoptotic process
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048850; hypophysis morphogenesis
GO:0060070; canonical Wnt signaling pathway
And 2 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005667; transcription factor complex
Function: GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205; transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001206; transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003682; chromatin binding
GO:0005515; protein binding
GO:0008013; beta-catenin binding
GO:0008022; protein C-terminus binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
CTNNB1
STRING interaction network
Protein-Protein network diagram for PROP1

Retrieve sequences for PROP1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
unc-42
Drosophila melanogaster
CG32532
Mus musculus
Prop1
Rattus norvegicus
Prop1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Prop1
GenDR gene manipulations
  • A homolog of this gene for Mus musculus is present as Prop1

Selected references

External links

EPD
ORF Accession
NM_006261
CDS Accession
NP_006252
OMIM
601538
HPRD
03325
Ensembl
PROP1
UniProt/Swiss-Prot
PROP1_HUMAN
GeneCards
PROP1
Entrez Gene
5626
GenAtlas
PROP1
Internet
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