GenAge entry for CTNNB1 (Homo sapiens)

Gene name (HAGRID: 223)

HGNC symbol
CTNNB1 
Aliases
beta-catenin; armadillo; CTNNB 
Common name
catenin (cadherin-associated protein), beta 1, 88kDa 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

CTNNB1, also known as beta-catenin, is a member of the adherens junctions proteins, involved in epithelial layers that mediate adhesion between cells, cell communication, growth, embryogenesis, and wound healing.

In roundworms, CTNNB1 has been associated with FOXO in oxidative stress signalling [1358]. In mice with a conditional mutation in CTNNB1 in the epidermis and hair follicles, if CTNNB1 was deleted, hair was completely lost after the first hair cycle, and without CTNNB1 skin stem cells failed to differentiate [1359]. CTNNB1 is also involved in Wnt signalling, which could play a role in adult stem cell self-renewal [1364]. Engraftment of young haematopoietic cells into old mice reverses the aged fracture phenotype and diminished osteoblastic differentiation capacity of old mice. CTNNB1 signalling was found to be important in this process. Temporal reduction of CTNNB1 during early fracture repair has been found to improve bone healing in old mice [4334].

Mutations in CTNNB1 have been associated with cancer in human patients [1362]. A role for CTNNB1 in human ageing is plausible though unconfirmed.

Cytogenetic information

Cytogenetic band
3p21
Location
41,199,451 bp to 41,240,448 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000578; embryonic axis specification
GO:0000904; cell morphogenesis involved in differentiation
GO:0001569; branching involved in blood vessel morphogenesis
GO:0001658; branching involved in ureteric bud morphogenesis
GO:0001701; in utero embryonic development
GO:0001702; gastrulation with mouth forming second
GO:0001708; cell fate specification
GO:0001711; endodermal cell fate commitment
GO:0001764; neuron migration
GO:0001837; epithelial to mesenchymal transition
And 127 more GO terms
Cellular component: GO:0000922; spindle pole
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005719; nuclear euchromatin
GO:0005737; cytoplasm
GO:0005813; centrosome
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005911; cell-cell junction
GO:0005912; adherens junction
And 26 more GO terms
Function: GO:0001085; RNA polymerase II transcription factor binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0003682; chromatin binding
GO:0003690; double-stranded DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0004871; signal transducer activity
GO:0005515; protein binding
GO:0008022; protein C-terminus binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
And 16 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
PROP1, LMNA, PTPN11, PTPN1, AKT1, EGFR, ERBB2, PARP1, BRCA1, PIN1, PTEN, CREBBP, HIF1A, EGR1, ABL1, TOP2A, NFKB1, EP300, PML, GSK3B, HTT, PRKCA, AR, HSPA8, EMD, FOXO3, FOXM1, UCHL1, APP, SIRT1, HDAC1, HSPA1B, MAPK8, YWHAZ, FGFR1, SP1, MAPK9, CCNA2, FAS, LMNB1, FOXO4, PIK3R1, TFAP2A, CREB1, ATF2, PTGS2, ESR1, PSEN1, PPARG, GSK3A, IKBKB
STRING interaction network
Protein-Protein network diagram for CTNNB1

Retrieve sequences for CTNNB1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ctnnb1
Drosophila melanogaster
arm
Mus musculus
Ctnnb1
Rattus norvegicus
Ctnnb1

Selected references

External links

EPD
ORF Accession
NM_001904
CDS Accession
NP_001895
OMIM
116806
HPRD
00286
Ensembl
CTNNB1
UniProt/Swiss-Prot
CTNB1_HUMAN
GeneCards
CTNNB1
Entrez Gene
1499
UniGene
476018
GenAtlas
CTNNB1
Internet
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