GenAge entry for BCL2 (Homo sapiens)

Gene name (HAGRID: 69)

HGNC symbol
BCL2 
Aliases
Bcl-2; PPP1R50 
Common name
B-cell CLL/lymphoma 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

BCL2 is an important suppressor of apoptosis and an oncogene. Apart from cancer, it may be involved in neurodegenerative disorders [447], and dendritic cell longevity in vivo has been reported to be controlled by BCL2 [1110]. BCL2 null mice die by six weeks of age with occurrence of grey hair though otherwise they do not appear to suffer from accelerated ageing [449]. In addition, some researchers have argued that BCL2's role in apoptosis suggests an involvement of BCL2 in ageing [942]. More detailed studies are necessary to investigate this possibility.

Cytogenetic information

Cytogenetic band
18q21.3
Location
63,123,346 bp to 63,319,380 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000209; protein polyubiquitination
GO:0001503; ossification
GO:0001541; ovarian follicle development
GO:0001656; metanephros development
GO:0001658; branching involved in ureteric bud morphogenesis
GO:0001662; behavioral fear response
GO:0001782; B cell homeostasis
GO:0001836; release of cytochrome c from mitochondria
GO:0001952; regulation of cell-matrix adhesion
GO:0002320; lymphoid progenitor cell differentiation
GO:0002326; B cell lineage commitment
And 101 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005741; mitochondrial outer membrane
GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0005829; cytosol
GO:0016020; membrane
GO:0031965; nuclear membrane
GO:0043209; myelin sheath
GO:0046930; pore complex
And 1 more GO terms
Function: GO:0002020; protease binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0015267; channel activity
GO:0016248; channel inhibitor activity
GO:0031625; ubiquitin protein ligase binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0043565; sequence-specific DNA binding
GO:0046982; protein heterodimerization activity
GO:0051434; BH3 domain binding
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, IRS1, IRS2, MYC, PPARA, PARP1, BRCA1, PIN1, HIF1A, BCL2, HSP90AA1, UBE2I, PML, BAX, SOD1, HSPA1A, MAPK8, CDK1, PSEN1, PPP1CA, CISD2, BAK1, IKBKB, SQSTM1
STRING interaction network
Protein-Protein network diagram for BCL2

Retrieve sequences for BCL2

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
bcl2
Mus musculus
Bcl2
Rattus norvegicus
Bcl2

Selected references

External links

EPD
HS_BCL2_2
ORF Accession
NM_000633
CDS Accession
NP_000624
OMIM
151430
HPRD
01045
Ensembl
BCL2
UniProt/Swiss-Prot
BCL2_HUMAN
GeneCards
BCL2
Entrez Gene
596
UniGene
150749
GenAtlas
BCL2
Internet
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