GenAge entry for HIC1 (Homo sapiens)

Gene name (HAGRID: 253)

HGNC symbol
HIC1 
Aliases
ZBTB29; ZNF901 
Common name
hypermethylated in cancer 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

HIC1 is a transcriptional repressor. It suppresses age-dependent development of cancer in mice together with TP53. HIC1 also forms a complex with SIRT1 that represses SIRT1 expression. Ageing increases promoter hypermethylation and epigenetic silencing of HIC1 [1582]. Therefore, HIC1 might play some role in ageing, though further studies are warranted.

Cytogenetic information

Cytogenetic band
17p13.3
Location
2,055,099 bp to 2,059,687 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-dependent
GO:0007275; multicellular organismal development
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016055; Wnt receptor signaling pathway
GO:0030178; negative regulation of Wnt receptor signaling pathway
GO:0043517; positive regulation of DNA damage response, signal transduction by p53 class mediator
Cellular component: GO:0000785; chromatin
GO:0005634; nucleus
GO:0005730; nucleolus
GO:0005737; cytoplasm
Function: GO:0003677; DNA binding
GO:0003700; sequence-specific DNA binding transcription factor activity
GO:0005515; protein binding
GO:0042826; histone deacetylase binding
GO:0043565; sequence-specific DNA binding
GO:0046872; metal ion binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
HDAC1
STRING interaction network
Protein-Protein network diagram for HIC1

Retrieve sequences for HIC1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
hic1
Mus musculus
Hic1
Rattus norvegicus
LOC100912068

Selected references

External links

EPD
ORF Accession
NM_006497
CDS Accession
NP_006488
OMIM
603825
HPRD
04826
Ensembl
HIC1
UniProt/Swiss-Prot
HIC1_HUMAN
GeneCards
HIC1
Entrez Gene
3090
UniGene
72956
GenAtlas
HIC1
Internet
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