GenAge entry for MT1E (Homo sapiens)

Gene name (HAGRID: 292)

HGNC symbol
MT1E 
Aliases
MTD; MT1 
Common name
metallothionein 1E 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

MT1E seems to play a role protecting against oxidative stress, although its exact functions are unknown. Cardiac-specific overexpression of MT1E in mice increased lifespan by 14% while attenuating oxidative stress in the heart [3251]. Further studies are warranted.

Cytogenetic information

Cytogenetic band
16q13
Location
56,625,673 bp to 56,627,113 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0045926; negative regulation of growth
GO:0071276; cellular response to cadmium ion
GO:0071294; cellular response to zinc ion
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0048471; perinuclear region of cytoplasm
Function: GO:0008270; zinc ion binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for MT1E

ORF
ORF
CDS
CDS

Homologs in model organisms

No homologs found

Selected references

External links

EPD
ORF Accession
NM_175617
CDS Accession
NP_783316
OMIM
156351
HPRD
01126
Ensembl
MT1E
UniProt/Swiss-Prot
MT1E_HUMAN
GeneCards
MT1E
Entrez Gene
4493
UniGene
744893
GenAtlas
MT1E
Internet
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