GenAge entry for NRG1 (Homo sapiens)

Gene name (HAGRID: 24)

HGNC symbol
NRG1 
Aliases
HRG; NDF; GGF; HGL; NRG1-IT2 
Common name
neuregulin 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

The NRG1 gene encodes multiple transcripts that appear to play a role in neuronal development, differentiation, and apoptosis [272]. It may be involved in neurodegenerative pathologies [1297], but it is unknown whether it plays a role in human ageing.

Cytogenetic information

Cytogenetic band
8p12
Location
32,646,732 bp to 32,743,252 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0000902; cell morphogenesis
GO:0003161; cardiac conduction system development
GO:0003222; ventricular trabecula myocardium morphogenesis
GO:0007154; cell communication
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171; activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0007399; nervous system development
GO:0007416; synapse assembly
GO:0007422; peripheral nervous system development
And 36 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005887; integral to plasma membrane
GO:0016020; membrane
GO:0016324; apical plasma membrane
GO:0030424; axon
GO:0031594; neuromuscular junction
Function: GO:0003712; transcription cofactor activity
GO:0005102; receptor binding
GO:0005125; cytokine activity
GO:0005176; ErbB-2 class receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0030296; protein tyrosine kinase activator activity
GO:0030297; transmembrane receptor protein tyrosine kinase activator activity
GO:0030971; receptor tyrosine kinase binding
GO:0043125; ErbB-3 class receptor binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EGFR, ERBB2, EGF
STRING interaction network
Protein-Protein network diagram for NRG1

Retrieve sequences for NRG1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
nrg1
Mus musculus
Nrg1
Rattus norvegicus
Nrg1

Selected references

External links

EPD
ORF Accession
NM_013959
CDS Accession
NP_039253
OMIM
142445
HPRD
00802
Ensembl
NRG1
UniProt/Swiss-Prot
NRG1_HUMAN
GeneCards
NRG1
Entrez Gene
3084
UniGene
453951
GenAtlas
NRG1
Internet
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