GenAge entry for HSF1 (Homo sapiens)

Gene name (HAGRID: 125)

HGNC symbol
HSF1 
Aliases
HSTF1 
Common name
heat shock transcription factor 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

A transcription factor that is activated upon heat shock, HSF1 regulates heat-shock response genes and has been associated with ageing in lower life forms. In roundworms, reducing the activity of a HSF1 homologue appears to accelerate ageing while overexpressing it extends lifespan [626]. In mammals, stress-response appears to diminish with age and it has been reported that HSF1 in aged rats exhibits a decreased ability to bind DNA [458]. Disruption of HSF1 in mice results in multiple defects, including increased prenatal lethality, growth retardation, female infertility, and increased susceptibility to stress [634]. Transgenic mutants overexpressing HSF-1 live longer (median lifespan ~50% higher) and are more thermotolerant [3545]. Although HSF1 has not been directly linked to human ageing, it is possible HSF1 plays some role in human ageing.

Cytogenetic information

Cytogenetic band
8q24.3
Location
144,291,588 bp to 144,314,722 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001892; embryonic placenta development
GO:0006468; protein phosphorylation
GO:0006952; defense response
GO:0007143; female meiotic division
GO:0007283; spermatogenesis
GO:0007584; response to nutrient
GO:0008285; negative regulation of cell proliferation
GO:0009299; mRNA transcription
GO:0010667; negative regulation of cardiac muscle cell apoptotic process
GO:0014823; response to activity
And 30 more GO terms
Cellular component: GO:0000791; euchromatin
GO:0000792; heterochromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0016605; PML body
GO:0043234; protein complex
GO:0045120; pronucleus
GO:0097165; nuclear stress granule
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001162; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0019901; protein kinase binding
GO:0031072; heat shock protein binding
GO:0042802; identical protein binding
GO:0043621; protein self-association
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
CREBBP, HSP90AA1, UBE2I, CEBPB, PRKDC, XRCC5, XRCC6, HSF1, SIRT1, HDAC1, HSPA1A, MAPK8, TBP, HSPA8, HDAC2, STUB1
STRING interaction network
Protein-Protein network diagram for HSF1

Retrieve sequences for HSF1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
hsf-1
Danio rerio
hsf1
Drosophila melanogaster
Hsf
Mus musculus
Hsf1
Rattus norvegicus
Hsf1
Schizosaccharomyces pombe
hsf1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as hsf-1
GenDR gene manipulations
  • A homolog of this gene for Caenorhabditis elegans is present as hsf-1

Selected references

External links

EPD
ORF Accession
NM_005526
CDS Accession
NP_005517
OMIM
140580
HPRD
00778
Ensembl
HSF1
UniProt/Swiss-Prot
HSF1_HUMAN
GeneCards
HSF1
Entrez Gene
3297
UniGene
530227
GenAtlas
HSF1
Internet
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