GenAge entry for HSF1 (Homo sapiens)

Gene name (HAGRID: 125)

HGNC symbol
HSF1 
Aliases
HSTF1 
Common name
heat shock transcription factor 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

A transcription factor that is activated upon heat shock, HSF1 regulates heat-shock response genes and has been associated with ageing in lower life forms. In roundworms, reducing the activity of a HSF1 homologue appears to accelerate ageing while overexpressing it extends lifespan [626]. In mammals, stress-response appears to diminish with age and it has been reported that HSF1 in aged rats exhibits a decreased ability to bind DNA [458]. Disruption of HSF1 in mice results in multiple defects, including increased prenatal lethality, growth retardation, female infertility, and increased susceptibility to stress [634]. Transgenic mutants overexpressing HSF-1 live longer (median lifespan ~50% higher) and are more thermotolerant [3545]. Although HSF1 has not been directly linked to human ageing, it is possible HSF1 plays some role in human ageing.

Cytogenetic information

Cytogenetic band
8q24.3
Location
144,291,588 bp to 144,314,722 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001892; embryonic placenta development
GO:0006351; transcription, DNA-templated
GO:0006468; protein phosphorylation
GO:0007143; female meiosis
GO:0007283; spermatogenesis
GO:0008285; negative regulation of cell proliferation
GO:0032496; response to lipopolysaccharide
GO:0032720; negative regulation of tumor necrosis factor production
GO:0034605; cellular response to heat
GO:0040018; positive regulation of multicellular organism growth
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
And 3 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0043234; protein complex
GO:0045120; pronucleus
Function: GO:0001162; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003682; chromatin binding
GO:0003700; sequence-specific DNA binding transcription factor activity
GO:0005515; protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
HSP90AA1, CEBPB, PRKDC, XRCC5, XRCC6, IL6, HSPA1A, MAPK9, TAF1, HSPA8
STRING interaction network
Protein-Protein network diagram for HSF1

Retrieve sequences for HSF1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
hsf-1
Drosophila melanogaster
Hsf
Danio rerio
hsf1
Mus musculus
Hsf1
Rattus norvegicus
Hsf1
Schizosaccharomyces pombe
hsf1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as hsf-1
GenDR gene manipulations
  • A homolog of this gene for Caenorhabditis elegans is present as hsf-1

Selected references

External links

EPD
ORF Accession
NM_005526
CDS Accession
NP_005517
OMIM
140580
HPRD
00778
Ensembl
HSF1
UniProt/Swiss-Prot
HSF1_HUMAN
GeneCards
HSF1
Entrez Gene
3297
UniGene
530227
GenAtlas
HSF1
Internet
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